Reactome | RCHY1 [nucleoplasm]

RCHY1 [nucleoplasm]

Stable Identifier

R-HSA-5655134

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RING finger and CHY zinc finger domain-containing protein 1, ZN363_HUMAN, Pirh2

Locations in the PathwayBrowser for interactor UniProt:Q96PM5 RCHY1

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External Reference Information

External Reference

UniProt:Q96PM5 RCHY1

Gene Names

RCHY1, ARNIP, CHIMP, PIRH2, RNF199, ZNF363

Chain

chain:1-261

Reference Genes

BioGPS Gene:25898 RCHY1

COSMIC (genes):RCHY1 RCHY1

CTD Gene:25898 RCHY1

dbSNP Gene:25898 RCHY1

ENSEMBL:ENSG00000163743 RCHY1

HGNC:17479 RCHY1

KEGG:hsa:25898 RCHY1

Monarch:25898 RCHY1

NCBI Gene:25898 RCHY1

OMIM:607680 RCHY1

UCSC:Q96PM5 RCHY1

Reference Transcript

Other Identifiers

11719570_at

11719571_a_at

16976908

212743_PM_at

212743_at

212749_PM_s_at

212749_s_at

214281_PM_s_at

214281_s_at

235300_PM_x_at

235300_x_at

25898

2773670

2773671

2773672

2773673

2773674

2773675

2773676

2773680

2773681

2773682

2773683

2773684

2773685

2773686

2773687

2773688

2773689

2773690

2773691

2773699

2773700

2773701

2773702

36046_at

64204_at

8101013

A_23_P350070

A_33_P3263841

GE56256

GO:0000151

GO:0002039

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006511

GO:0008270

GO:0016567

GO:0016607

GO:0016740

GO:0031398

GO:0032436

GO:0042803

GO:0043226

GO:0043231

GO:0046872

GO:0051865

GO:0061630

GO:0070987

GO:0072344

GO:0140096

HMNXSV003010846

Hs.279864.1.A1_3p_s_at

Hs.29153.0.A1_3p_at

Hs.48297.0.S2_3p_at

ILMN_1722698

ILMN_2386732

PH_hs_0003386

TC04001298.hg

TC04002599.hg

Participates

as an output of

RCHY1 monoubiquitinates POLH (Homo sapiens)

as a component of

POLH:RCHY1 [nucleoplasm] (Homo sapiens)

as an input of

RCHY1 binds POLH (Homo sapiens)

This entity regulates

Negatively

POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)

Other forms of this molecule

RCHY1 [cytosol]

Inferred To

RCHY1 [nucleoplasm] (Bos taurus)

RCHY1 [nucleoplasm] (Canis familiaris)

RCHY1 [nucleoplasm] (Mus musculus)

RCHY1 [nucleoplasm] (Plasmodium falciparum)

RCHY1 [nucleoplasm] (Rattus norvegicus)

RCHY1 [nucleoplasm] (Sus scrofa)

rchy1 [nucleoplasm] (Danio rerio)

rchy1 [nucleoplasm] (Xenopus tropicalis)

Rchy1 [nucleoplasm] (Drosophila melanogaster)

Rchy1 [nucleoplasm] (Gallus gallus)

Homologues of RCHY1 [nucleoplasm] (Plasmodium falciparum)

Cross References

RefSeq

NP_001265467.1, NP_001265466.1, NP_001265465.1, NP_056251.2, NP_001009922.1

OpenTargets

ENSG00000163743

ENSEMBL

ENST00000507014, ENSP00000321239, ENSP00000424472, ENSP00000424631, ENST00000380840, ENST00000513257, ENST00000505105, ENST00000512706, ENSP00000421084, ENSP00000423976, ENST00000324439, ENSP00000370220

HPA

ENSG00000163743-RCHY1

PRO

Q96PM5

Pharos - Targets

Q96PM5

PDB

2K2D, 2K2C, 2JRJ, 7YNX

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.892	13
UniProt:Q8TF42 UBS3B			0.782	8
UniProt:O60662 KLHL41	1	KLHL41 [cytosol] (R-HSA-8863222)	0.718	6
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.632	5
UniProt:Q9NVV5 AIG1			0.602	4
UniProt:P0C6X7-PRO_0000037311 REP			0.59	9
UniProt:Q9C0C4 SEM4C			0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q7Z4I7-5 LIMS2			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
IntAct:EBI-10204203 25796			0.556	3
UniProt:Q6RFH5 WDR74			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q5T7V8 GORAB			0.553	2
UniProt:P0DTD1-PRO_0000449621 REP			0.547	2
UniProt:P18085 ARF4	1	ARF4 [cytosol] (R-HSA-5618178)	0.543	3
UniProt:P04196 HRG	3	HRG [plasma membrane] (R-HSA-158927) HRG [extracellular region] (R-HSA-158699) HRG [platelet alpha granule lumen] (R-HSA-56661)	0.543	3
UniProt:P62158 CALM			0.524	2
UniProt:K9N7C7-PRO_0000422441 REP			0.508	2
UniProt:Q969F2 NKD2			0.508	2
UniProt:Q6UXH0 ANGPTL8	1	ANGPTL8 [extracellular region] (R-HSA-6784850)	0.508	2
UniProt:P0C6X5-PRO_0000283876 REP			0.508	2
UniProt:Q13557 CAMK2D	5	p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [cytosol] (R-HSA-445370)	0.499	2
UniProt:Q96PM5 RCHY1	2	RCHY1 [cytosol] (R-HSA-976013) RCHY1 [nucleoplasm] (R-HSA-5655134)	0.488	2

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