Reactome | MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]

MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]

Stable Identifier

R-HSA-5655163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Monoubiquitinated DNA Polymerase Eta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y253 POLH

Gene Names

POLH, RAD30, RAD30A, XPV

Chain

chain:1-713

Reference Genes

BioGPS Gene:5429 POLH

COSMIC (genes):POLH POLH

CTD Gene:5429 POLH

dbSNP Gene:5429 POLH

ENSEMBL:ENSG00000170734 POLH

HGNC:9181 POLH

KEGG Gene (Homo sapiens):5429 POLH

Monarch:5429 POLH

NCBI Gene:5429 POLH

OMIM:603968 POLH

UCSC:Q9Y253 POLH

Reference Transcript

Other Identifiers

0002640132

11729178_at

11729179_x_at

11752223_x_at

11754902_a_at

1557701_PM_s_at

1557701_s_at

17009054

219380_3p_x_at

219380_PM_x_at

219380_x_at

222879_PM_s_at

222879_s_at

231115_PM_at

231115_at

233852_PM_at

233852_at

2908101

2908103

2908104

2908105

2908108

2908109

2908118

2908119

2908120

2908121

2908122

2908123

2908124

2908125

2908126

2908127

2908128

2908129

2908130

2908131

2908132

2908133

2908134

2908135

2908136

2908141

2908143

5429

8119858

81712_at

A_14_P113059

A_14_P118268

A_32_P69492

A_32_P96692

GE79909

GO:0000731

GO:0003674

GO:0003677

GO:0003684

GO:0003887

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006260

GO:0006281

GO:0006282

GO:0006290

GO:0006301

GO:0006950

GO:0006974

GO:0008150

GO:0009058

GO:0009314

GO:0010225

GO:0016740

GO:0016779

GO:0034641

GO:0035861

GO:0042276

GO:0043167

GO:0043226

GO:0046872

GO:0070987

GO:0071494

GO:0071897

HMNXSV003025742

HMNXSV003026209

Hs.123140.0.A1_3p_at

Hs.155573.1.S1_3p_at

Hs2.407274.1.A1_3p_s_at

ILMN_1658221

ILMN_2136576

PH_hs_0009372

TC06000605.hg

g5457143_3p_a_at

Participates

as a component of

MonoUb:K682,K686,K694,K709-POLH [nucleoplasm] (Homo sapiens)

Other forms of this molecule

POLH [nucleoplasm]

Inferred To

polh [nucleoplasm] (Danio rerio)

polh [nucleoplasm] (Xenopus tropicalis)

POLH [nucleoplasm] (Bos taurus)

POLH [nucleoplasm] (Canis familiaris)

POLH [nucleoplasm] (Gallus gallus)

POLH [nucleoplasm] (Sus scrofa)

PolH [nucleoplasm] (Drosophila melanogaster)

Polh [nucleoplasm] (Mus musculus)

Polh [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine at 682

Coordinate

682

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine at 686

Coordinate

686

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine at 694

Coordinate

694

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine at 709

Coordinate

709

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001278899.1, NP_006493.1

OpenTargets

ENSG00000170734

ZINC - Substances

POLH_HUMAN

ZINC - Biogenic

POLH_HUMAN

ZINC target

Q9Y253

PRO

Q9Y253

PDB

3SI8, 5F9N, 4O3N, 5L1L, 5KFF, 5EWF, 5KFR, 6PL8, 7M7Z, 6MQ8, 5DLF, 5KFD, 5KFV, 4YR2, 7M81, 4DL6, 7M7S, 7M88, 4ECV, 7M8D, 4RU9, 6M7T, 6V5K, 4YR0, 5KFB, 4RNM, 4J9R, 5KG0, 5KFT, 5KFH, 5DGB, 6UQI, 3MR2, 4ED7, 7M8A, 4J9Q, 7M7Y, 5KFX, 7M7P, 4ED2, 5KG3, 7M8B, 5DG9, 6M7O, 6MXO, 6Q02, 4DL7, 7M85, 5KFW, 4Q8E, 7M7Q, 5KG2, 2LSK, 5KFK, 5KFQ, 5JUM, 4J9N, 5DG8, 3MR5, 5L1J, 5DQH, 4J9S, 5KG1, 7M7M, 4ECY, 5KFO, 4ECT, 5KG6, 4YP3, 3WUP, 4RNO, 4ED0, 7M84, 4DL3, 6M7V, 4ED6, 4O3P, 5KG4, 4DL4, 3JAA, 4ECW, 6WK6, 4DL2, 5DQI, 5KFE, 5DLG, 4ED3, 7M86, 6PZ3, 6M7P, 7M87, 5KFJ, 4YR3, 5F9L, 3MR3, 4J9M, 6UI2, 5KFI, 7M82, 5KFU, 5L1I, 4DL5, 4YQW, 7M89, 7M83, 4ECU, 4O3R, 4J9P, 5KFG, 4ECR, 5KFS, 5KFA, 6D0M, 5KFY, 5KFM, 4ECS, 6PL7, 3MR6, 4ECQ, 5EWG, 5EWE, 5DGA, 5KFL, 4J9O, 7M80, 5L1K, 7M7R, 4O3S, 7M8C, 4J9L, 5KG7, 5KFP, 7M7L, 4ED1, 2I5O, 3TQ1, 6D0Z, 5DG7, 5DQG, 4J9K, 6PLC, 6MP3, 4ED8, 5KFC, 4EEY, 5KFZ, 6M7U, 4RNN, 5KG5, 7M7T, 7M7N, 4ECZ, 4O3Q, 5L9X, 7M7U, 5KFN, 6W5X, 4O3O, 7M7O, 4ECX, 4Q8F

IntEnz

2.7.7.7

HPA

ENSG00000170734-POLH

GeneCards

Q9Y253

Ensembl

ENST00000372236, ENSG00000170734, ENST00000372226, ENSP00000361300, ENSP00000361310

Pharos - Targets

Q9Y253

Orphanet

15120

HMDB Protein

HMDBP00957

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.676	6
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.672	7
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-566-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-338-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-186-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-262-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-414-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-110-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-642-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-488-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.658	4
UniProt:Q6FI35 Q6FI35			0.527	3
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.471	2

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