POLK and POLZ cooperate in elongation of mispaired primer termini

Stable Identifier
R-HSA-5655965
Type
Reaction [transition]
Species
Homo sapiens
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DNA polymerase kappa (POLK) can elongate mispaired primer termini generated when an incorrect nucleotide is incorporated opposite a damaged DNA base either by POLK or by another translesion DNA synthesis (TLS) polymerase (Haracska et al. 2002, Carlson et al. 2006). POLK can processively synthesize polynucleotide chains that are usually not more than 20 nucleotides long, generating single base substitutions at a rate of 7/1000 and single base deletions at a rate of 3/1000 (Ohashi et al. 2000). POLK and POLZ can cooperate in the elongation of nucleotides inserted opposite to lesioned bases by POLK (Yoon et al. 2010, Wojtaszek et al. 2012a, Wojtaszek et al. 2012b, Xie et al. 2012, Yoon et al. 2014)

Literature References
PubMed ID Title Journal Year
23143872 Structural insights into the assembly of human translesion polymerase complexes

Xie, W, Yang, X, Xu, M, Jiang, T

Protein Cell 2012
11006276 Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

Ohashi, E, Bebenek, K, Matsuda, T, Feaver, WJ, Gerlach, VL, Friedberg, EC, Ohmori, H, Kunkel, TA

J. Biol. Chem. 2000
22859295 Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ?, and Pol ?

Wojtaszek, J, Lee, CJ, D'Souza, S, Minesinger, B, Kim, H, D'Andrea, AD, Walker, GC, Zhou, P

J. Biol. Chem. 2012
12444249 Role of human DNA polymerase kappa as an extender in translesion synthesis

Haracska, L, Prakash, L, Prakash, S

Proc. Natl. Acad. Sci. U.S.A. 2002
22700975 Multifaceted recognition of vertebrate Rev1 by translesion polymerases ? and ?

Wojtaszek, J, Liu, J, D'Souza, S, Wang, S, Xue, Y, Walker, GC, Zhou, P

J. Biol. Chem. 2012
17043239 Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini

Carlson, KD, Johnson, RE, Prakash, L, Prakash, S, Washington, MT

Proc. Natl. Acad. Sci. U.S.A. 2006
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Catalyst Activity
Title
DNA-directed DNA polymerase activity of POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm]
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Orthologous Events
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