Reactome | POLI [nucleoplasm]

POLI [nucleoplasm]

Stable Identifier

R-HSA-5656133

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA polymerase iota

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UNA4 POLI

Gene Names

POLI, RAD30B

Chain

chain:1-740

Reference Genes

BioGPS Gene:11201 POLI

COSMIC (genes):POLI POLI

CTD Gene:11201 POLI

dbSNP Gene:11201 POLI

ENSEMBL:ENSG00000101751 POLI

HGNC:9182 POLI

KEGG:hsa:11201 POLI

Monarch:11201 POLI

NCBI Gene:11201 POLI

OMIM:605252 POLI

UCSC:Q9UNA4 POLI

Reference Transcript

RefSeq:NM_007195.2 POLI

Other Identifiers

11201

11721419_at

11755435_a_at

11758286_s_at

16852433

219317_PM_at

219317_at

238992_PM_at

238992_at

3788834

3788835

3788836

3788837

3788838

3788839

3788840

3788841

3788842

3788843

3788845

3788847

3788849

3788850

3788851

3788852

3788853

3788854

3788855

3788856

3788857

3788858

3788860

3788861

3788862

3788863

3788864

3788865

3788868

3788869

43932_at

74219_at

8021275

A_14_P125156

A_23_P306890

GE62743

GO:0003677

GO:0003684

GO:0003824

GO:0003887

GO:0005515

GO:0005634

GO:0005654

GO:0006259

GO:0006260

GO:0006281

GO:0016607

GO:0016740

GO:0019985

GO:0036464

GO:0042276

GO:0043226

GO:0046872

GO:0071897

GO:0140097

HMNXSV003008709

Hs.128076.0.A1_3p_at

ILMN_1702218

PH_hs_0025673

TC18000186.hg

g6005847_3p_at

Participates

as a member of

DNA polymerase Y [nucleoplasm] (Homo sapiens)

as a component of

POLI:Mg2+ [nucleoplasm] (Homo sapiens)

Inferred To

Poli [nucleoplasm] (Rattus norvegicus)

Ghost homologue of POLI [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of POLI [nucleoplasm] (Gallus gallus)

Ghost homologue of POLI [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of POLI [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of POLI [nucleoplasm] (Schizosaccharomyces pombe)

poli [nucleoplasm] (Danio rerio)

poli [nucleoplasm] (Xenopus tropicalis)

POLI [nucleoplasm] (Bos taurus)

POLI [nucleoplasm] (Canis familiaris)

POLI [nucleoplasm] (Drosophila melanogaster)

POLI [nucleoplasm] (Mus musculus)

POLI [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000101751

ENSEMBL

ENSG00000101751, ENST00000579534, ENSP00000462664

HPA

ENSG00000101751-POLI

GeneCards

POLI

PRO

Q9UNA4

Pharos - Targets

Q9UNA4

GlyGen

Q9UNA4

HMDB Protein

HMDBP00969

PDB

3Q8Q, 5KT4, 3G6X, 5ULX, 2DPJ, 3GV8, 2DPI, 3Q8P, 2KHW, 2KTF, 5KT5, 3G6Y, 2FLP, 3OSN, 3EPG, 2L0F, 2L0G, 3EPI, 3H40, 4FS1, 4EYH, 2MBB, 2KHU, 4EYI, 3H4B, 3G6V, 1T3N, 4EBE, 5KT2, 2FLL, 5KT3, 3GV7, 3H4D, 2FLN, 5ULW, 3NGD, 3Q8R, 2ALZ, 4FS2, 5KT7, 5KT6, 4EBC, 3Q8S, 3GV5, 1ZET, 4EBD

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.553	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.527	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.524	2

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