POLZ elongates POLI-incorporated dNMP

Stable Identifier
R-HSA-5656158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After it incorporates a dNMP opposite to a damaged template base, DNA polymerase iota (POLI) is unable to efficiently elongate the DNA strand further. The elongation step is performed by the DNA polymerase zeta complex (POLZ), composed of REV3L and MAD2L2 subunits (Johnson et al. 2000). POLK has also been implicated in the elongation step (Washington et al. 2004).

Literature References
PubMed ID Title Journal Year
15199127 Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa

Washington, MT, Minko, IG, Johnson, RE, Wolfle, WT, Harris, TM, Lloyd, RS, Prakash, S, Prakash, L

Mol. Cell. Biol. 2004
10984059 Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

Johnson, RE, Washington, MT, Haracska, L, Prakash, S, Prakash, L

Nature 2000
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Catalyst Activity
Title
DNA-directed DNA polymerase activity of POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm]
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Activity
Orthologous Events
Cross References
Target Pathogen
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