Termination of translesion DNA synthesis

Stable Identifier
R-HSA-5656169
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. Since monoubiquitination of PCNA at lysine residue K164 is a prerequisite for the assembly of TLS complexes on damaged DNA templates, PCNA deubiquitination is a key step in TLS termination that allows DNA polymerase switching from Y family DNA polymerases involved in TLS to replicative DNA polymerases delta and epsilon (Povlsen et al. 2012, Park et al. 2014).

Participants
Participant Of
Orthologous Events
Cross References
BioModels Database