Reactome | RHEB [endosome membrane]

RHEB [endosome membrane]

Stable Identifier

R-HSA-5656350

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Rheb

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15382 RHEB

Gene Names

RHEB, RHEB2

Chain

chain:1-181, propeptide:182-184

Reference Genes

BioGPS Gene:6009 RHEB

COSMIC (genes):RHEB RHEB

CTD Gene:6009 RHEB

dbSNP Gene:6009 RHEB

ENSEMBL:ENSG00000106615 RHEB

HGNC:10011 RHEB

KEGG:hsa:6009 RHEB

Monarch:6009 RHEB

NCBI Gene:6009 RHEB

OMIM:601293 RHEB

UCSC:Q15382 RHEB

Reference Transcript

RefSeq:NM_005614.4 RHEB

Other forms of this molecule

RHEB [lysosomal membrane]

Inferred To

RHEB [endosome membrane] (Bos taurus)

RHEB [endosome membrane] (Canis familiaris)

RHEB [endosome membrane] (Sus scrofa)

Rheb [endosome membrane] (Drosophila melanogaster)

Rheb [endosome membrane] (Mus musculus)

Rheb [endosome membrane] (Rattus norvegicus)

rheb [endosome membrane] (Danio rerio)

rheb [endosome membrane] (Dictyostelium discoideum)

rheb [endosome membrane] (Xenopus tropicalis)

rheb-1 [endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005605.1

ENSEMBL

ENSG00000106615, ENST00000262187, ENSP00000262187

OpenTargets

ENSG00000106615

GeneCards

RHEB

HPA

ENSG00000106615-RHEB

PRO

Q15382

Pharos - Targets

Q15382

HMDB Protein

HMDBP08547

PDB

5YXH, 1XTQ, 7BTA, 1XTR, 7BTD, 3T5G, 6BT0, 6BSX, 6BCU, 7BTC, 1XTS, 3SEA

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.527	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.527	2
UniProt:Q9UHF4 IL20RA	1	IL20RA [plasma membrane] (R-HSA-448713)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2

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