MGMT-mediated DNA damage reversal

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R-HSA-5657655
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Homo sapiens
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Reactive cellular catabolites can cause DNA damage by 6-O-methylation of guanine. 6-O-methylguanine can pair ambiguously with both C and T, and cause transition mutations. Active reversal of such damage can be facilitated by MGMT, a protein that has 6-O-methylguanine-DNA methyltransferase activity (Mitra and Kaina 1993).

Literature References
PubMed ID Title Journal Year
8434121 Regulation of repair of alkylation damage in mammalian genomes.

Mitra, S, Kaina, B

Prog Nucleic Acid Res Mol Biol 1993
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