Synphilin-1 (SNCAIP) binds alpha-synuclein (SNCAs) in vivo, which promotes the formation of Lewy body-like inclusions that are characteristic of Parkinson's Disease (Engelender et al. 1999, Kawamata et al. 2001). SNCAIP and PARK2 (Parkin) are found in the central core of a majority of Lewy Bodies in Parkinson's disease (Bandopadhyay et al. 2005).