Reactome | SPRED3 [plasma membrane]

SPRED3 [plasma membrane]

Stable Identifier

R-HSA-5658223

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - RAS signaling downstream of NF1 loss-of-function variants (Homo sapiens)
      - Loss-of-function NF1 variants don't stimulate RAS GTPase activity (Homo sapiens)
        
        NF1 GTPase mutants:SPRED dimer:p21 RAS:GTP [plasma membrane] (Homo sapiens)
        
        SPRED dimer [plasma membrane] (Homo sapiens)
        
        SPRED3 dimer [plasma membrane] (Homo sapiens)
        
        SPRED3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q2MJR0 SPRED3

Gene Names

SPRED3, EVE-3

Chain

chain:1-410

Reference Genes

BioGPS Gene:399473 SPRED3

COSMIC (genes):SPRED3 SPRED3

CTD Gene:399473 SPRED3

dbSNP Gene:399473 SPRED3

ENSEMBL:ENSG00000188766 SPRED3

ENSEMBL_homo_sapiens_GENE:ENSG00000188766.13 SPRED3

HGNC:31041 SPRED3

KEGG Gene (Homo sapiens):399473 SPRED3

Monarch:399473 SPRED3

NCBI Gene:399473 SPRED3

OMIM:609293 SPRED3

UCSC:Q2MJR0 SPRED3

Reference Transcript

Other Identifiers

11735564_at

11738951_a_at

16861714

230046_PM_at

230046_at

3832407

3832408

3832409

3832411

3832412

3832416

3832417

3832418

3832419

3832420

3832421

3832422

3832423

3832424

3832425

3832426

3832427

3832428

3832429

3832431

3832432

3832434

399473

77755_at

8028389

A_33_P3401981

GE505778

GE507652

GO:0005886

GO:0007275

GO:0009966

GO:0010719

GO:0016020

GO:0019901

GO:0023052

GO:0030154

GO:0030512

GO:0043409

GO:0048856

GO:0070373

GO:1902747

HMNXSV003008160

Hs.196011.0.A1_3p_at

ILMN_2275110

ILMN_2410194

PH_hs_0033689

TC19000528.hg

Participates

as a component of

SPRED3 dimer [plasma membrane] (Homo sapiens)

Inferred To

Spred [plasma membrane] (Drosophila melanogaster)

spred3 [plasma membrane] (Xenopus tropicalis)

Spred3 [plasma membrane] (Mus musculus)

Spred3 [plasma membrane] (Rattus norvegicus)

SPRED3 [plasma membrane] (Canis familiaris)

SPRED3 [plasma membrane] (Sus scrofa)

vasp [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001035987.1, XP_006723282.1

OpenTargets

ENSG00000188766

GeneCards

Q2MJR0

HPA

ENSG00000188766-SPRED3

Ensembl

ENSP00000510478, ENSG00000188766, ENST00000691638, ENSP00000466568, ENSP00000345405, ENST00000338502, ENST00000586301

PRO

Q2MJR0

Pharos - Targets

Q2MJR0