FGFRL1 modulation of FGFR1 signaling

Stable Identifier
R-HSA-5658623
Type
Pathway
Species
Homo sapiens
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FGFRL1 is a fifth member of the FGFR family of receptors. The extracellular region has 40% sequence similarity with FGFR1-4, but FGFRL1 lacks the internal kinase domain of the other FGF receptors and how it acts in FGFR signaling is unclear. Some models suggest FGFRL1 restricts canonical FGFR signaling by sequestering ligand away from kinase-active receptors, while other models suggest that FGFRL1 may promote canonical signaling by nucleating signaling complexes or enhancing ERK1/2 activation (reviewed in Trueb, 2011; Trueb et al, 2013).

Literature References
PubMed ID Title Journal Year
23112089 Role of FGFRL1 and other FGF signaling proteins in early kidney development

Trueb, B, Amann, R, Gerber, SD

Cell. Mol. Life Sci. 2013
21080029 Biology of FGFRL1, the fifth fibroblast growth factor receptor

Trueb, B

Cell. Mol. Life Sci. 2011
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