Reactome | SNCB [cytosol]

SNCB [cytosol]

Stable Identifier

R-HSA-5660390

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Beta-synuclein, SYUB_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8NDC4

Expand all

Literature References

PubMed ID	Title	Journal	Year
8194594	Identification of two distinct synucleins from human brain Spillantini, MG, Goedert, M, Jakes, R	FEBS Lett.	1994

External Reference Information

External Reference

UniProt:Q16143 SNCB

Gene Names

SNCB

Chain

chain:1-134

Reference Genes

BioGPS Gene:6620 SNCB

COSMIC (genes):SNCB SNCB

CTD Gene:6620 SNCB

dbSNP Gene:6620 SNCB

ENSEMBL:ENSG00000074317 SNCB

ENSEMBL_homo_sapiens_GENE:ENSG00000074317.11 SNCB

HGNC:11140 SNCB

KEGG Gene (Homo sapiens):6620 SNCB

Monarch:6620 SNCB

NCBI Gene:6620 SNCB

OMIM:602569 SNCB

UCSC:Q16143 SNCB

Reference Transcript

Other Identifiers

11723790_a_at

11739785_a_at

17003103

207853_PM_s_at

207853_s_at

2888402

2888403

2888404

2888405

2888407

2888408

2888409

2888410

2888411

2888412

2888413

40753_at

6620

8115948

A_23_P121945

GE58296

GO:0004859

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0007268

GO:0012501

GO:0016192

GO:0016234

GO:0023052

GO:0034330

GO:0042417

GO:0043025

GO:0043524

GO:0043679

GO:0045202

GO:0046914

GO:0048488

GO:0050808

GO:0051402

GO:0098772

GO:1903136

HMNXSV003032960

HMNXSV003049798

HMNXSV003050383

ILMN_1755366

ILMN_1779343

ILMN_2397841

ILMN_2397842

ILMN_2397846

PH_hs_0005042

S69965_at

TC05002096.hg

g6466453_3p_a_at

Participates

as an output of

Expression of SNCB (Homo sapiens)

Cross References

RefSeq

NP_001001502.1, XP_006714979.1, NP_003076.1

OpenTargets

ENSG00000074317

HPA

ENSG00000074317-SNCB

GeneCards

Q16143

Ensembl

ENST00000310112, ENSG00000074317, ENSP00000422223, ENST00000510387, ENST00000393693, ENSP00000424073, ENSP00000308057, ENST00000506696, ENSP00000377296

PRO

Q16143

Pharos - Targets

Q16143

Orphanet

17217

HMDB Protein

HMDBP08696

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NDC4 MORN4			0.718	6
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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