MTF1 activates gene expression

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R-HSA-5660489
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Pathway
Species
Homo sapiens
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The MTF1:zinc complex in the nucleus binds Metal Response Elements (MREs), DNA containing the core consensus sequence 5'-TGCRCNC-3', and activates or represses transcription depending on the context of the MRE (reviewed in Laity and Andrews 2007, Jackson et al. 2008, Gunther et al. 2012, Grzywacz et al. 2015). The 6 zinc fingers of each MTF1 monomer have different affinities for zinc and evidence from the mouse homolog indicates that different concentrations of zinc, and hence different metal loads in MTF1, activate different subsets of target genes (Wang et al. 2004, Dong et al. 2015). Genes activated by MTF1 include those encoding metallothioneins, zinc transporters, and stress-response proteins (Hardyman et al. 2016).

Literature References
PubMed ID Title Journal Year
19021537 Mechanisms of mammalian zinc-regulated gene expression

Jackson, KA, Valentine, RA, Coneyworth, LJ, Mathers, JC, Ford, D

Biochem. Soc. Trans. 2008
26336656 Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level

Grzywacz, A, Gdula-Argasińska, J, Muszyńska, B, Tyszka-Czochara, M, Librowski, T, Opoka, W

Acta Biochim. Pol. 2015
25405524 Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review)

Dong, G, Chen, H, Qi, M, Dou, Y, Wang, Q

Mol Med Rep 2015
26824222 Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

Hardyman, JE, Tyson, J, Jackson, KA, Aldridge, C, Cockell, SJ, Wakeling, LA, Valentine, RA, Ford, D

Metallomics 2016
17462582 Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)

Laity, JH, Andrews, GK

Arch. Biochem. Biophys. 2007
15318811 Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration

Wang, Y, Lorenzi, I, Georgiev, O, Schaffner, W

Biol. Chem. 2004
22289350 The taste of heavy metals: gene regulation by MTF-1

Günther, V, Lindert, U, Schaffner, W

Biochim. Biophys. Acta 2012
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