Reactome | UCHL1 [cytosol]

UCHL1 [cytosol]

Stable Identifier

R-HSA-5660679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCHL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P09936 UCHL1

Gene Names

UCHL1

Chain

chain:1-220, propeptide:221-223

Reference Genes

BioGPS Gene:7345 UCHL1

COSMIC (genes):UCHL1 UCHL1

CTD Gene:7345 UCHL1

dbSNP Gene:7345 UCHL1

ENSEMBL:ENSG00000154277 UCHL1

HGNC:12513 UCHL1

KEGG Gene (Homo sapiens):7345 UCHL1

Monarch:7345 UCHL1

NCBI Gene:7345 UCHL1

OMIM:191342 UCHL1

Reference Transcript

RefSeq:NM_004181.4 UCHL1

Other Identifiers

0006980112

11754803_s_at

11757915_s_at

11758672_s_at

11758680_s_at

16966285

201387_s_at

2580

2725032

2725033

2725034

2725035

2725038

2725041

2725042

2725043

2725044

2725047

2725048

2725052

2725053

2725054

2725055

2725056

2ETL

2LEN

36990_at

3IFW

3IRT

3KVF

3KW5

4DM9

4JKJ

5993

7345

79024

8094778

A_23_P132956

AAD09172

AAH00332

AAH05117

AAH06305

AAY40923

AC095043

ACI46047

ACV87176

AH007277

BC000332

BC005117

BC006305

CAA28443

CAA35249

CAB002580

CAB079024

CCDS3462

CH471069

D6R956

D6R974

D6RE83

D6RF53

D6RJD9

EAW92983

ENSG00000154277

ENSP00000284440

ENSP00000422542

ENST00000284440

ENST00000284440.8

ENST00000503431

ENST00000503431.5

EntrezGene:7345

EntrezGene:UCHL1

FJ224355

g4759283_3p_s_at

GE81358

GO:0000902

GO:0002931

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006464

GO:0006508

GO:0006511

GO:0006810

GO:0006914

GO:0006950

GO:0007165

GO:0007409

GO:0007412

GO:0007628

GO:0008150

GO:0008233

GO:0008234

GO:0008242

GO:0008283

GO:0009056

GO:0016020

GO:0016241

GO:0016579

GO:0016787

GO:0016874

GO:0019233

GO:0019896

GO:0019899

GO:0030154

GO:0030424

GO:0030705

GO:0031625

GO:0031694

GO:0032182

GO:0036459

GO:0042755

GO:0043025

GO:0043130

GO:0043161

GO:0043226

GO:0043407

GO:0044306

GO:0048747

GO:0048856

GO:0050877

GO:0050905

GO:1904115

GQ472201

HEL-117

HGNC:12513

HPA005993

ILMN_1757387

IPR001578

IPR030297

IPR036959

IPR038765

MIM:191342

MIM:613643

MIM:615491

NM_004181

NP_004172

PF01088

PH_hs_0004392

PR00707

TC04000253.hg

UCHL1

UCHL1-201

UCHL1-204

UPI00001379CA

V9HW74

X04741

X04741_at

X17377

Participant Of

hasMember

UCHL1,UCHL3 [cytosol]

Inferred To

UCHL1 [cytosol] (Bos taurus)

UCHL1 [cytosol] (Caenorhabditis elegans)

UCHL1 [cytosol] (Canis familiaris)

UCHL1 [cytosol] (Danio rerio)

UCHL1 [cytosol] (Dictyostelium discoideum)

UCHL1 [cytosol] (Drosophila melanogaster)

UCHL1 [cytosol] (Gallus gallus)

UCHL1 [cytosol] (Mus musculus)

UCHL1 [cytosol] (Plasmodium falciparum)

UCHL1 [cytosol] (Rattus norvegicus)

UCHL1 [cytosol] (Xenopus tropicalis)

Homologues of UCHL1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004172.2

OpenTargets

ENSG00000154277

IntEnz

3.4.19.12

ZINC - Substances

UCHL1_HUMAN

GeneCards

P09936

ZINC target

P09936

PRO

P09936

Orphanet

15682

ZINC - Predictions - Purchasable

UCHL1_HUMAN

PDB

3IRT, 2LEN, 3IFW, 4DM9, 3KW5, 4JKJ, 3KVF, 2ETL

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.508	2
UniProt:P46527 CDKN1B	8	p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.463	2