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UCHL1 [cytosol]
Stable Identifier
R-HSA-5660679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCHL1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)
UCHL1,UCHL3 [cytosol] (Homo sapiens)
UCHL1 [cytosol] (Homo sapiens)
UCHL1,UCHL3:Ub [cytosol] (Homo sapiens)
UCHL1,UCHL3 [cytosol] (Homo sapiens)
UCHL1 [cytosol] (Homo sapiens)
UCHL1,UCHL3:Ub-Lys [cytosol] (Homo sapiens)
UCHL1,UCHL3 [cytosol] (Homo sapiens)
UCHL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09936 UCHL1
Gene Names
UCHL1
Chain
chain:1-220, propeptide:221-223
Reference Genes
BioGPS Gene:7345 UCHL1
COSMIC (genes):UCHL1 UCHL1
CTD Gene:7345 UCHL1
dbSNP Gene:7345 UCHL1
ENSEMBL:ENSG00000154277 UCHL1
HGNC:12513 UCHL1
KEGG Gene (Homo sapiens):7345 UCHL1
Monarch:7345 UCHL1
NCBI Gene:7345 UCHL1
OMIM:191342 UCHL1
Reference Transcript
RefSeq:NM_004181.4 UCHL1
Other Identifiers
0006980112
11754803_s_at
11757915_s_at
11758672_s_at
11758680_s_at
16966285
201387_PM_s_at
201387_s_at
2725032
2725033
2725034
2725035
2725038
2725041
2725042
2725043
2725044
2725047
2725048
2725052
2725053
2725054
2725055
2725056
36990_at
7345
8094778
A_23_P132956
GE81358
GO:0000902
GO:0002931
GO:0003674
GO:0004197
GO:0004843
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006464
GO:0006508
GO:0006511
GO:0006810
GO:0006914
GO:0006950
GO:0007165
GO:0007409
GO:0007412
GO:0007628
GO:0008150
GO:0008233
GO:0008234
GO:0008242
GO:0008283
GO:0009056
GO:0016020
GO:0016241
GO:0016579
GO:0016787
GO:0016874
GO:0019233
GO:0019896
GO:0019899
GO:0030154
GO:0030424
GO:0030705
GO:0031625
GO:0031694
GO:0032182
GO:0042755
GO:0043025
GO:0043130
GO:0043161
GO:0043226
GO:0043407
GO:0044306
GO:0048856
GO:0050877
GO:0050905
GO:0055001
GO:0071466
GO:1904115
HMNXSV003019625
ILMN_1757387
PH_hs_0004392
TC04000253.hg
X04741_at
g4759283_3p_s_at
Participates
as a member of
UCHL1,UCHL3 [cytosol] (Homo sapiens)
Inferred To
UCH-L1 [cytosol]
(Gallus gallus)
UCHL3 [cytosol]
(Plasmodium falciparum)
ubh-2 [cytosol]
(Caenorhabditis elegans)
uchl1 [cytosol]
(Danio rerio)
uchl1 [cytosol]
(Xenopus tropicalis)
ubh-3 [cytosol]
(Caenorhabditis elegans)
Uchl1 [cytosol]
(Mus musculus)
Uchl1 [cytosol]
(Rattus norvegicus)
uch1 [cytosol]
(Dictyostelium discoideum)
UCHL1 [cytosol]
(Bos taurus)
UCHL1 [cytosol]
(Canis familiaris)
UCHL1 [cytosol]
(Sus scrofa)
Homologues of UCHL1 [cytosol]
(Caenorhabditis elegans)
Uch [cytosol]
(Drosophila melanogaster)
ubh-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_004172.2
Guide to Pharmacology - Targets
2426
OpenTargets
ENSG00000154277
ZINC - FDA approved
UCHL1_HUMAN
ZINC - Substances
UCHL1_HUMAN
ZINC target
P09936
PRO
P09936
PDB
4DM9
,
4JKJ
,
3KW5
,
3IFW
,
2LEN
,
2ETL
,
3KVF
,
3IRT
ZINC - Investigational
UCHL1_HUMAN
HPA
ENSG00000154277-UCHL1
GeneCards
P09936
Ensembl
ENSP00000284440
,
ENST00000284440
,
ENST00000503431
,
ENSP00000422542
,
ENSG00000154277
Pharos - Targets
P09936
ZINC - Predictions - Purchasable
UCHL1_HUMAN
Orphanet
15682
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.703
5
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
0.675
4
UniProt:Q9H1Y0 ATG5
3
ATG5 [phagocytic vesicle membrane]
(R-HSA-5205636)
GlyK130-ATG5 [cytosol]
(R-HSA-5683582)
ATG5 [cytosol]
(R-HSA-936010)
0.675
4
UniProt:Q14164 IKBKE
4
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.675
4
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-88) [cytosol]
(R-HSA-6782654)
NEDD8(1-88) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.666
4
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.666
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
CDK4 [nucleoplasm]
(R-HSA-113843)
0.591
4
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.556
3
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.556
3
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.556
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.499
2
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.463
2
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