Reactome: A Curated Pathway Database

USP9X deubiquitinates Ub-SNCA

Stable Identifier
R-HSA-5660752
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The deubiquitinase USP9X binds and deubiquitinates alpha-synuclein (SNCA) in vitro and in vivo, showing co-accumulation with SNCA in Lewy Bodies. Knockdown of USP9X expression in conditions of proteolytic inhibition leads to the accumulation of monoubiquitinated SNCA and increases the aggregation of SNCA into toxic inclusions, strengthening the connection between monoubiquitination, inclusion formation, and toxicity of SNCA. USP9X cytosolic levels are lower in Diffuse Lewy Body disease and Parkinson's Disease tissues, which may contribute to the accumulation and aggregation of monoubiquitinated SNCA (Rott et al. 2011).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cysteine-type peptidase activity of USP9X:Ub-SNCA [cytosol] USP9X:Ub-SNCA [cytosol] cysteine-type peptidase activity (0008234)