Reactome: A Curated Pathway Database

KDM2A, KDM2B, KDM4A, KDM8 demethylate Me2K37-histone H3

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

All characterised lysine demethylases other than KDM1A belong to the jumonji C-domain (JmjC) containing family, members of the Cupin superfamily of mononuclear Fe (II)-dependent oxygenases. They require 2-oxoglutarate (2-OG) and molecular oxygen as co-substrates, producing succinate and carbon dioxide. This hydroxylation-based mechanism does not require a protonatable lysine epsilon-amine group and consequently JmjC-containing demethylases are able to demethylate tri-, di- and monomethylated lyines.

The first reported JmjC-containing demethylases were KDM2A and KDM2B (JHDM1A/B, FBXL11/10). These demethylate lysine-37 of histone H3 when mono- or di-methylated (H3K36Me1/2) (Tsukada et al. 2006). KDM4A (JHDM3A) can demethylate mono-, di and trimethylated lysine-37 of histone H3 (Klose et al. 2006). KDM8 can demethylate diimethylated lysine-37 of histone H3 (Hsia et al. 2010).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
histone demethylase activity of KDM2A, KDM2B, KDM4A, KDM8 [nucleoplasm] KDM2A, KDM2B, KDM4A, KDM8 [nucleoplasm] histone demethylase activity (0032452)
Orthologous Events