CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3

Stable Identifier
R-HSA-5661117
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CCND1:CDK4:PRMT5:pT5-WDR77 methylates MeR9-histone H3
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Histone H3 arginine-9 (H3R8) dimethylation is a PRMT5-specific mark (Pal et al. 2004) associated with gene silencing (Chen et al. 1999, Pal et al. 2004, 2007).

Literature References
PubMed ID Title Journal Year
15485929 Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

Pal, S, Vishwanath, SN, Erdjument-Bromage, H, Tempst, P, Sif, S

Mol. Cell. Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-arginine N-methyltransferase activity of CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created