JMJD6 demethylates MeR4-HIST1H4

Stable Identifier
R-HSA-5661124
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JMJD6 catalyses demethylation of mono- or di-methylated arginine-3 of histone H3 (H3R2Me1/2) and arginine-4 of histone H4 (H4R3Me1/2) (Chang et al. 2007). Non-histone substrates of JMJD6 arginine demethylation have also been reported (Poulard et al. 2014, Lawrence et al. 2014). Subsequent to its characterization as an arginine demethylase, JMJD6 was reported to be a lysine hydroxylase (Webby et al 2009).

Literature References
PubMed ID Title Journal Year
17947579 JMJD6 is a histone arginine demethylase Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of JMJD6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events