JMJD6 demethylates Me2sR4-HIST1H4

Stable Identifier
R-HSA-5661125
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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JMJD6 demethylates Me2sR4-HIST1H4
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JMJD6 catalyses demethylation of mono- or di-methylated arginine-3 of histone H3 (H3R2Me1/2) and arginine-4 of histone H4 (H4R3Me1/2) (Chang et al. 2007). Non-histone substrates of JMJD6 arginine demethylation have also been reported (Poulard et al. 2014, Lawrence et al. 2014). Subsequent to its characterization as an arginine demethylase, JMJD6 was reported to be a lysine hydroxylase (Webby et al 2009).

Literature References
PubMed ID Title Journal Year
17947579 JMJD6 is a histone arginine demethylase

Chang, B, Chen, Y, Zhao, Y, Bruick, RK

Science 2007
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of JMJD6 [nucleoplasm]
Physical Entity
JMJD6 [nucleoplasm]
Activity
histone demethylase activity (0032452)
Orthologous Events
JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)
JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)
JMJD6 demethylates Me2sR4-HIST1H4 (Canis familiaris)
JMJD6 demethylates Me2sR4-HIST1H4 (Dictyostelium discoideum)
JMJD6 demethylates Me2sR4-HIST1H4 (Drosophila melanogaster)
JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)
JMJD6 demethylates Me2sR4-HIST1H4 (Mus musculus)
JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)
JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)
JMJD6 demethylates Me2sR4-HIST1H4 (Xenopus tropicalis)
Authored
Jupe, S  (2013-03-12)
Reviewed
Schofield, CJ  (2014-05-08)
Walport, LJ  (2014-05-08)
Hopkinson, J  (2014-05-08)
Created
Jupe, S  (2015-01-09)