Reactome: A Curated Pathway Database

JMJD6 demethylates Me2sR4-HIST1H4

Stable Identifier
R-HSA-5661125
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JMJD6 catalyses demethylation of mono- or di-methylated arginine-3 of histone H3 (H3R2Me1/2) and arginine-4 of histone H4 (H4R3Me1/2) (Chang et al. 2007). Non-histone substrates of JMJD6 arginine demethylation have also been reported (Poulard et al. 2014, Lawrence et al. 2014). Subsequent to its characterization as an arginine demethylase, JMJD6 was reported to be a lysine hydroxylase (Webby et al 2009).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
histone demethylase activity of JMJD6 [nucleoplasm] JMJD6 [nucleoplasm] histone demethylase activity (0032452)
Orthologous Events