LRRK2 [cytosol]

Stable Identifier
R-HSA-5661173
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Leucine-rich repeat serine/threonine-protein kinase 2 ecNumber2.7.11.1/ecNumber, LRRK2_HUMAN, PARK8
Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1
External Reference Information
External Reference
Gene Names
LRRK2, PARK8
Chain
chain:1-2527
Reference Transcript
Other Identifiers
11735294_a_at
11735295_a_at
120892
16749939
229584_PM_at
229584_at
3411329
3411330
3411332
3411333
3411335
3411336
3411337
3411341
3411343
3411344
3411345
3411346
3411347
3411348
3411349
3411350
3411351
3411354
3411355
3411356
3411357
3411358
3411359
3411360
3411361
3411362
3411363
3411364
3411365
3411366
3411368
3411369
3411371
3411372
3411373
3411374
3411376
3411377
3411379
3411380
3411381
3411383
3411385
3411386
3411389
3411391
3411392
3411394
3411396
3411397
3411398
3411399
3411402
3411404
3411405
3411407
3411408
3411411
3411413
3411414
3411415
51362_at
7954810
81790_at
A_23_P128447
A_33_P3369058
GE79036
GE798909
GO:0000139
GO:0000149
GO:0000165
GO:0000166
GO:0000287
GO:0001933
GO:0001934
GO:0002376
GO:0003779
GO:0003824
GO:0003924
GO:0004672
GO:0004674
GO:0004706
GO:0004709
GO:0005096
GO:0005102
GO:0005515
GO:0005524
GO:0005525
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005759
GO:0005764
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005798
GO:0005802
GO:0005829
GO:0005856
GO:0005886
GO:0005902
GO:0006468
GO:0006606
GO:0006886
GO:0006897
GO:0006913
GO:0006914
GO:0006954
GO:0006979
GO:0007005
GO:0007029
GO:0007030
GO:0007040
GO:0007254
GO:0007266
GO:0007283
GO:0007528
GO:0008017
GO:0008021
GO:0008092
GO:0008104
GO:0008340
GO:0009267
GO:0009966
GO:0010468
GO:0010506
GO:0010508
GO:0010738
GO:0010955
GO:0010977
GO:0012501
GO:0014041
GO:0015631
GO:0016020
GO:0016192
GO:0016242
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0016787
GO:0017075
GO:0018105
GO:0018107
GO:0019722
GO:0021756
GO:0021772
GO:0022028
GO:0022414
GO:0023052
GO:0030154
GO:0030159
GO:0030163
GO:0030276
GO:0030424
GO:0030425
GO:0030426
GO:0030672
GO:0031267
GO:0031398
GO:0031410
GO:0031647
GO:0031966
GO:0032091
GO:0032092
GO:0032436
GO:0032473
GO:0032760
GO:0032839
GO:0034211
GO:0034260
GO:0034330
GO:0034599
GO:0034614
GO:0035556
GO:0035564
GO:0035640
GO:0035641
GO:0035751
GO:0036211
GO:0036479
GO:0039706
GO:0040012
GO:0042391
GO:0042802
GO:0042803
GO:0042995
GO:0043005
GO:0043025
GO:0043068
GO:0043195
GO:0043204
GO:0043226
GO:0043231
GO:0043406
GO:0044325
GO:0044753
GO:0044754
GO:0045121
GO:0045202
GO:0045860
GO:0046039
GO:0046777
GO:0048312
GO:0048812
GO:0048856
GO:0048870
GO:0050877
GO:0051018
GO:0051604
GO:0051646
GO:0051770
GO:0051900
GO:0051966
GO:0055086
GO:0060070
GO:0060079
GO:0060090
GO:0060159
GO:0060161
GO:0060628
GO:0060828
GO:0061001
GO:0065003
GO:0070062
GO:0070585
GO:0070971
GO:0070973
GO:0071287
GO:0071356
GO:0071407
GO:0090140
GO:0090263
GO:0090394
GO:0097487
GO:0098772
GO:0098794
GO:0098978
GO:0099400
GO:0099523
GO:0106310
GO:0140058
GO:0140096
GO:1900242
GO:1900244
GO:1901135
GO:1902236
GO:1902499
GO:1902692
GO:1902803
GO:1902823
GO:1902902
GO:1903125
GO:1903215
GO:1903217
GO:1903351
GO:1903980
GO:1904713
GO:1904887
GO:1905279
GO:1905289
GO:1990904
GO:1990909
GO:2000172
GO:2000300
GO:2000377
HMNXSV003035165
Hs.124292.0.A1_3p_at
ILMN_2226015
PH_hs_0022858
PH_hs_0041186
TC12000309.hg
Participates
Inferred To
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
IntEnz
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (243)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q5S007 LRRK2  1 0.986 68
 GTP [ChEBI:15996]  7 0.976 26
 UniProt:P26038 MSN  4 0.956 19
 UniProt:O00429 DNM1L  2 0.91 16
 UniProt:P63104 YWHAZ  2 0.907 11
 UniProt:Q16543 CDC37  1 0.882 10
 UniProt:P27348 YWHAQ  1 0.862 10
 UniProt:P62258 YWHAE  1 0.823 8
 UniProt:P61981 YWHAG  1 0.821 26
 UniProt:P11142 HSPA8  10 0.813 6
 UniProt:P30048 PRDX3  1 0.796 14
 UniProt:O14976 GAK  3 0.793 11
 UniProt:P07900 HSP90AA1  8 0.788 7
 UniProt:P08238 HSP90AB1  6 0.788 7
 GDP [ChEBI:17552]  7 0.786 8
 UniProt:Q04917 YWHAH  1 0.784 6
 UniProt:P62841 RPS15  2 0.783 9
 UniProt:P61006 RAB8A  6 0.77 9
 UniProt:P61020 RAB5B  8 0.761 9
 UniProt:O14966 RAB29  2 0.761 15
 UniProt:Q13637 RAB32  3 0.753 12
 UniProt:P31946 YWHAB  1 0.75 5
 UniProt:P07437 TUBB  3 0.744 6
 IntAct:EBI-6312987 NICTIDE      0.73 4
 UniProt:P05060 CHGB  2 0.73 3
 UniProt:Q9UL15 BAG5  1 0.718 12
 UniProt:Q14155 ARHGEF7  1 0.715 7
 UniProt:P30084 ECHS1  17 0.713 4
 UniProt:Q9UNE7 STUB1  1 0.713 4
 UniProt:P31947 SFN  1 0.713 5
 UniProt:P60866 RPS20  2 0.688 4
 UniProt:P61026 RAB10  5 0.688 7
 UniProt:Q8WUM0 NUP133  2 0.688 4
 UniProt:Q13191 CBLB  1 0.683 4
 UniProt:P10636-8 MAPT  3 0.676 9
 UniProt:P04350 TUBB4A  6 0.67 6
 UniProt:Q13501 SQSTM1  7 0.67 18
 UniProt:P39053  3 0.669 3
 UniProt:O95295 SNAPIN  2 0.66 5
 UniProt:O75581 LRP6  8 0.657 4
 UniProt:P61983  1 0.65 6
 UniProt:O15027 SEC16A  1 0.649 8
 UniProt:P49841 GSK3B  4 0.645 7
 UniProt:P19338 NCL  3 0.643 4
 UniProt:P62280 RPS11  2 0.642 5
 UniProt:P23396 RPS3  2 0.642 4
 UniProt:P26373 RPL13  1 0.642 4
 UniProt:P62906 RPL10A  1 0.642 4
 UniProt:P42677 RPS27  2 0.642 4
 UniProt:P62249 RPS16  2 0.642 4
 UniProt:P15880 RPS2  3 0.642 4
 UniProt:P63151 PPP2R2A  2 0.641 4
 UniProt:P62136 PPP1CA  1 0.64 6
 UniProt:O14641 DVL2  5 0.632 5
 UniProt:Q9NQU5 PAK6  1 0.623 2
 UniProt:Q8N8V4 ANS4B      0.623 2
 UniProt:P02687 MBP      0.623 3
 UniProt:Q9UKI2 CDC42EP3  2 0.623 2
 ChEBI:132484 MLI-2      0.623 2
 UniProt:Q96PY6 NEK1  1 0.623 2
 UniProt:O95816 BAG2  1 0.623 3
 UniProt:Q9NWM3 CUED1      0.623 2
 ChEBI:78408 GUANOSINE 5'-[BETA,GAMMA-IMIDO]TRIPHOSPHATE      0.623 5
 UniProt:P42679 MATK  1 0.623 2
 UniProt:Q99962 SH3GL2  4 0.623 4
 UniProt:P20700 LMNB1  8 0.623 4
 UniProt:Q7L592 NDUFAF7  1 0.623 2
 UniProt:P60953 CDC42  3 0.621 3
 UniProt:P46821-PRO_0000018605 MAP1B      0.611 5
 UniProt:Q62848  1 0.61 7
 UniProt:O55143  2 0.602 13
 UniProt:O60313 OPA1  4 0.602 5
 UniProt:P55060 XPO2      0.597 4
 UniProt:Q92973 TNPO1  2 0.597 4
 UniProt:O00231 PSMD11  5 0.597 4
 UniProt:P62269 RPS18  2 0.59 3
 UniProt:Q9Y6A4 CFA20      0.59 3
 UniProt:Q99961 SH3GL1  1 0.59 3
 UniProt:Q6P3X3 TTC27      0.59 3
 UniProt:O95218 ZRAB2      0.59 2
 UniProt:P49406 MRPL19  1 0.59 3
 UniProt:Q4G0J3 LARP7      0.59 3
 UniProt:P62277 RPS13  2 0.59 3
 UniProt:P49207 RPL34  1 0.59 3
 UniProt:O43865 AHCYL1  1 0.59 3
 UniProt:P62888 RPL30  1 0.59 3
 UniProt:Q9BQ70 TCF25      0.59 3
 UniProt:Q9H0U4 RAB1B  8 0.59 5
 UniProt:Q71RC2 LARP4      0.59 3
 UniProt:Q12972 PPP1R8  1 0.59 3
 UniProt:P17612 PRKACA  4 0.59 6
 UniProt:Q53GS9 USP39  1 0.59 3
 UniProt:P46734 MAP2K3  3 0.589 5
 UniProt:Q38SD2 LRRK1      0.589 5
 UniProt:P41220 RGS2  1 0.571 6
 UniProt:Q05639 EEF1A2  1 0.564 3
 UniProt:P05141 SLC25A5  1 0.564 2
 UniProt:O00203 AP3B1  4 0.564 2
 UniProt:Q03252 LMNB2      0.564 3
 UniProt:P12236 SLC25A6  2 0.564 2
 UniProt:Q9UKV8 AGO2  2 0.564 3
 UniProt:P12235 SLC25A4  3 0.564 2
 UniProt:P21796 VDAC1  7 0.564 3
 ChEBI:78374 GPPNHP      0.558 2
 UniProt:P57729 RAB38  3 0.558 4
 UniProt:Q13469 NFATC2  4 0.558 3
 UniProt:P31749 AKT1  14 0.558 6
 UniProt:Q8NHS9 SPT22      0.556 3
 UniProt:P48730-2 CSNK1D      0.556 3
 IntAct:EBI-25831191 CCSB      0.556 3
 UniProt:Q9BUL9 RPP25  1 0.556 3
 UniProt:P60896 SEM1  2 0.556 3
 UniProt:P37840 SNCA  5 0.556 6
 UniProt:P63000 RAC1  6 0.556 5
 UniProt:Q8N6T3 ARFGAP1  1 0.554 2
 UniProt:P68371 TUBB4B  8 0.547 3
 UniProt:Q9BUF5 TUBB6  6 0.547 3
 UniProt:Q13885 TUBB2A  6 0.547 3
 UniProt:Q8N6T3-2 ARFGAP1      0.544 6
 UniProt:Q92997 DVL3  4 0.543 4
 UniProt:O14640-2 DVL1      0.543 7
 UniProt:Q9Y6I7 WSB1  1 0.543 5
 UniProt:Q05193 DNM1  3 0.543 4
 UniProt:Q9DBG3  5 0.527 2
 UniProt:Q9JIS5 SV2A      0.527 2
 UniProt:P62829 RPL23  1 0.527 3
 UniProt:Q68FD5  6 0.527 2
 UniProt:P62259 Ywhae  1 0.527 2
 UniProt:P14618 PKM  3 0.527 3
 UniProt:P39023 RPL3  1 0.527 3
 UniProt:Q16531 DDB1  1 0.527 3
 UniProt:Q01813 PFKP  1 0.527 3
 UniProt:O00159 MYO1C  1 0.527 3
 UniProt:P10155 RO60      0.527 3
 UniProt:P61264  1 0.527 2
 UniProt:P62913 RPL11  1 0.527 3
 UniProt:Q96T76 MMS19  1 0.527 3
 UniProt:Q9NU22 MDN1      0.527 3
 UniProt:P23258 TUBG1  1 0.527 3
 UniProt:Q9P035 HACD3  1 0.527 3
 UniProt:P05388 RPLP0  1 0.527 3
 UniProt:P83731 RPL24  1 0.527 3
 UniProt:P63261 ACTG1  3 0.527 3
 UniProt:P49411 TUFM  2 0.527 3
 UniProt:P50402 EMD  4 0.527 3
 UniProt:O43795 MYO1B      0.527 3
 UniProt:Q96EY7 PTCD3  1 0.527 3
 UniProt:P12270 TPR  5 0.527 3
 UniProt:Q13435 SF3B2  1 0.527 3
 UniProt:Q9UBF2 COPG2  4 0.527 3
 UniProt:P09543 CN37      0.527 3
 UniProt:P68373 Tuba1c  6 0.527 2
 UniProt:Q8N1G4 LRC47      0.527 3
 UniProt:Q8NI60 COQ8A  1 0.527 3
 UniProt:Q9UN37 VPS4A  1 0.527 3
 UniProt:O15269 SPTLC1  1 0.527 3
 UniProt:P99024 Tubb5  4 0.527 2
 UniProt:Q71U36 TUBA1A  9 0.527 2
 UniProt:P57740 NUP107  2 0.527 3
 UniProt:Q9H9B4 SFXN1      0.527 3
 UniProt:P07814 EPRS1  1 0.527 3
 UniProt:P49790 NUP153  1 0.527 3
 UniProt:Q15393 SF3B3  1 0.527 3
 UniProt:Q969V3 NCLN      0.527 3
 UniProt:O95831 AIFM1      0.527 3
 UniProt:O00139 KIF2A  1 0.527 3
 UniProt:Q9H4L4 SENP3  1 0.527 3
 UniProt:P84098 RPL19  1 0.527 3
 UniProt:Q61548  1 0.527 2
 UniProt:P49368 CCT3  1 0.527 3
 UniProt:Q12769 NUP160  2 0.527 3
 UniProt:Q02978 SLC25A11  1 0.527 3
 UniProt:Q5S006  1 0.527 2
 UniProt:Q7L576 CYFIP1  5 0.527 3
 UniProt:P48047 ATP5PO  1 0.527 3
 UniProt:P51571 SSR4  1 0.527 3
 UniProt:P30050 RPL12  1 0.527 3
 UniProt:P13995 MTHFD2  1 0.527 3
 UniProt:Q9H936 SLC25A22  1 0.527 3
 UniProt:P11216 PYGB  4 0.527 3
 UniProt:Q9UNF1 MAGED2  2 0.527 3
 UniProt:Q5UIP0 RIF1  1 0.527 3
 UniProt:O60610 DIAPH1  4 0.527 2
 UniProt:Q14008 CKAP5  1 0.527 3
 UniProt:P42166 TMPO      0.527 3
 UniProt:Q13724 MOGS  3 0.527 3
 UniProt:P05213 Tuba1b  10 0.527 2
 UniProt:Q9Y230 RUVBL2  1 0.527 3
 UniProt:Q14739 LBR  4 0.527 3
 UniProt:Q9Y3Z3 SAMHD1  1 0.527 3
 UniProt:O94906 PRPF6  1 0.527 3
 UniProt:Q9Y4W2 LAS1L  1 0.527 3
 UniProt:P26641 EEF1G  3 0.527 3
 UniProt:Q16186 ADRM1  2 0.527 3
 UniProt:Q9Y2L1 DIS3  2 0.527 3
 UniProt:P62263 RPS14  2 0.527 3
 UniProt:P62081 RPS7  2 0.527 3
 UniProt:O00273 DFFA  6 0.527 3
 UniProt:Q13185 CBX3  1 0.527 3
 UniProt:Q92945 KHSRP  4 0.527 3
 UniProt:O00410 IPO5  1 0.527 3
 UniProt:Q16576 RBBP7  1 0.527 3
 UniProt:Q9UKV3 ACIN1  4 0.527 3
 UniProt:O35526 Stx1a  3 0.527 2
 UniProt:P07901 Hsp90aa1  7 0.527 2
 UniProt:Q15008 PSMD6  5 0.527 3
 UniProt:P49792 RANBP2  6 0.527 3
 UniProt:P38646 HSPA9  6 0.527 3
 UniProt:P62244 RPS15A  2 0.527 3
 UniProt:P61221 ABCE1  2 0.527 3
 UniProt:Q86WJ1 CHD1L  1 0.527 3
 UniProt:P00338 LDHA  2 0.527 3
 UniProt:Q14498 RBM39  1 0.527 3
 UniProt:P78527 PRKDC  4 0.527 3
 UniProt:P12004 PCNA  5 0.527 3
 UniProt:Q13200 PSMD2  5 0.527 3
 UniProt:P43246 MSH2  3 0.527 3
 UniProt:P11499  5 0.527 2
 UniProt:P31689 DNAJA1  2 0.527 3
 UniProt:P46782 RPS5  2 0.527 3
 UniProt:P13639 EEF2  10 0.527 3
 UniProt:Q14974 KPNB1  5 0.527 3
 UniProt:P46460  1 0.527 5
 UniProt:P61247 RPS3A  2 0.527 3
 UniProt:P62266 RPS23  3 0.525 2
 UniProt:P62750 RPL23A  1 0.525 2
 UniProt:P50914 RPL14  1 0.525 2
 UniProt:P07195 LDHB  1 0.525 2
 UniProt:P12369 Prkar2b  3 0.524 3
 UniProt:P30275  1 0.524 2
 UniProt:P61021  6 0.499 2
 UniProt:Q6IQ22 RAB12  3 0.499 2
 UniProt:Q13158 FADD  1 0.499 4
 UniProt:Q13509 TUBB3  6 0.482 2
 UniProt:Q91YQ1  2 0.463 2
 UniProt:Q63481  2 0.463 3
 UniProt:O95140 MFN2  5 0.463 3
 UniProt:Q811U4  5 0.463 3
 UniProt:Q32KD4  6 0.463 2
 UniProt:P13473 LAMP2  5 0.463 2
 UniProt:P52564 MAP2K6  3 0.463 4
 UniProt:P46940 IQGAP1  3 0.462 2
 UniProt:P30153 PPP2R1A  2 0.462 2
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