MT1A binds arsenic

Stable Identifier
R-HSA-5661230
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Metallothionein MT1A binds 6 atoms of arsenic(III), 3 atoms at the N-terminal beta domain and 3 atoms at the C-terminal alpha domain (Ngu and Stillman 2006, Irvine et al. 2013). Each arsenic atom binds 3 cysteine thiols (Ngu and Stillman 2006, Irvine et al. 2013).

Literature References
PubMed ID Title Journal Year
23523794 Cysteine accessibility during As3+ metalation of the ?- and ?-domains of recombinant human MT1a

Irvine, GW, Summers, KL, Stillman, MJ

Biochem. Biophys. Res. Commun. 2013
16984198 Arsenic binding to human metallothionein

Ngu, TT, Stillman, MJ

J. Am. Chem. Soc. 2006
Participants
Participant Of
Orthologous Events
Authored
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Created