KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose

Stable Identifier
R-HSA-5662473
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
dehydro-L-gulonate decarboxylase decarboxylates 3-dehydro-L-gulonate to L-xylulose, 3-dehydro-L-gulonate => L-xylulose + CO2
ReviewStatus
5/5
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KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose
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Cytosolic dehydro-L-gulonate decarboxylase (KGPDC) catalyzes the conversion of 3-dehydro-L-gulonate to L-xylulose and CO2. Studies in vivo provide indirect but strong evidence that this reaction occurs in humans and guinea pigs and dehydro-L-gulonate decarboxylase enzyme has been partially purified from guinea pigs (Winkelman & Ashwell 1961). Its amino acid sequence is unknown, however.
Literature References
PubMed ID Title Journal Year
14007506 Enzymic formation of L-xylulose from beeta-keto-L-gulonic acid

Winkelman, J, Ashwell, G

Biochim. Biophys. Acta 1961
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Catalyst Activity

dehydro-L-gulonate decarboxylase activity of KGPDC [cytosol]

Physical Entity
KGPDC [cytosol] (Homo sapiens)
Activity
dehydro-L-gulonate decarboxylase activity (GO:0047842)
Cross References
Rhea
Authored
D'Eustachio, P  (2015-08-14)
Reviewed
Jassal, B  (2015-08-14)
Created
D'Eustachio, P  (2015-01-12)
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