FMNL2 binds RHOC:GTP

Stable Identifier
R-HSA-5665748
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FMNL2 specifically interacts with the GTP-bound RHOC, which relieves FMNL2 autoinhibition and contributes to RHOC-mediated ameboid cell motility involved in cancer cell invasion (Kitzing et al. 2010). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL2 (Moriya et al. 2012).

Literature References
PubMed ID Title Journal Year
22790947 Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3

Moriya, K, Yamamoto, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Fukushige, D, Kimoto, C, Suzuki, T, Utsumi, T

Biosci. Biotechnol. Biochem. 2012
20101212 Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

Kitzing, TM, Wang, Y, Pertz, O, Copeland, JW, Grosse, R

Oncogene 2010
Participants
Participant Of
Orthologous Events
Authored