Reactome: A Curated Pathway Database

FMNL2 binds RHOC:GTP

Stable Identifier
R-HSA-5665748
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FMNL2 specifically interacts with the GTP-bound RHOC, which relieves FMNL2 autoinhibition and contributes to RHOC-mediated ameboid cell motility involved in cancer cell invasion (Kitzing et al. 2010). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL2 (Moriya et al. 2012).

Literature References
Participants
Participant Of
Orthologous Events