Reactome: A Curated Pathway Database

CDC42:GTP:FMNL2 binds Profilin:G-actin

Stable Identifier
R-HSA-5665751
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once activated by binding to GTP-bound CDC42, FMNL2 interacts with actin bound profilin(s) and drives elongation but not nucleation of actin filaments (Block et al. 2012). The interaction between formins and profilins is achieved through the proline-rich FH1 domain of formins, while the interaction with actin is achieved through the FH2 domain of formins (Romero et al. 2004, Kovar et al. 2006, Kuhn and Geyer 2014).

Literature References
Participants
Participant Of
Orthologous Events