FMNL3 binds RHOC:GTP

Stable Identifier
R-HSA-5665761
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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FMNL3 binds RHOC:GTP
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FMNL3 binds activated (GTP-bound) RHOC. RHOC-mediated activation of FMNL3 promotes polarized cell migration which may be involved in cancer cell invasion (Vega et al. 2011). Myristoylation of the N-terminal glycine may be required for the full activation of FMNL3 (Moriya et al. 2012).
Literature References
PubMed ID Title Journal Year
15006353 Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture

Sagot, I, Moseley, JB, Poy, F, Eck, MJ, Goode, BL, Pellman, D, Xu, Y

Cell 2004
24914801 Formins as effector proteins of Rho GTPases

Kühn, S, Geyer, M

Small GTPases 2014
21576392 RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

Ridley, AJ, Vega, FM, Fruhwirth, G, Ng, T

J. Cell Biol. 2011
22790947 Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3

Suzuki, T, Utsumi, T, Takamitsu, E, Matsunaga, Y, Kimoto, M, Moriya, K, Fukushige, D, Yamamoto, T, Kimoto, C

Biosci. Biotechnol. Biochem. 2012
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Orthologous Events
FMNL3 binds RHOC:GTP (Bos taurus)
FMNL3 binds RHOC:GTP (Canis familiaris)
FMNL3 binds RHOC:GTP (Gallus gallus)
FMNL3 binds RHOC:GTP (Mus musculus)
FMNL3 binds RHOC:GTP (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-20)
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