Reactome: A Curated Pathway Database

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments

Stable Identifier
R-HSA-5665809
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SRGAP2 is a GTPase activating protein that stimulates the GTPase activity of RAC1 bound to FMNL1. GTP hydrolysis produces inactive GDP-bound RAC1 which is unable to bind and activate FMNL1. SRGAP2 thereby limits the duration of FMNL1-mediated elongation of actin filaments downstream of RAC1:GTP (Mason et al. 2011).

Literature References
PubMed ID Title Journal Year
21148482 Bi-modal regulation of a formin by srGAP2 J. Biol. Chem. 2011
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
GTPase activity of SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] GTPase activity (0003924)