Reactome | ADRM1 [cytosol]

ADRM1 [cytosol]

Stable Identifier

R-HSA-5665939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasomal ubiquitin receptor ADRM1, ADRM1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16186 ADRM1

Gene Names

ADRM1, GP110

Chain

initiator methionine:1, chain:2-407

Reference Genes

BioGPS Gene:11047 ADRM1

COSMIC (genes):ADRM1 ADRM1

CTD Gene:11047 ADRM1

dbSNP Gene:11047 ADRM1

ENSEMBL:ENSG00000130706 ADRM1

ENSEMBL:ENSG00000130706.13 ADRM1

HGNC:15759 ADRM1

KEGG Gene (Homo sapiens):11047 ADRM1

Monarch:11047 ADRM1

NCBI Gene:11047 ADRM1

OMIM:610650 ADRM1

UCSC:Q16186 ADRM1

Reference Transcript

Other Identifiers

11047

11716498_s_at

11716499_x_at

11750079_a_at

16915656

201281_PM_at

201281_at

38808_at

3892612

3892614

3892618

3892621

3892622

3892628

3892633

3892637

3892638

3892639

3892641

3892642

3892644

3892646

3892647

3892648

8063893

A_14_P126714

A_23_P68665

A_24_P305597

D64154_at

GE57289

GO:0000502

GO:0002020

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006368

GO:0008541

GO:0030163

GO:0043161

GO:0043226

GO:0043248

GO:0061133

GO:0065003

GO:0070628

GO:0098772

GO:0140678

HMNXSV003021553

ILMN_1760143

ILMN_2389013

PH_hs_0005036

TC20000487.hg

g5901959_3p_at

Participates

as an input of

ADRM1 binds 26S proteasome (Homo sapiens)

as a component of

ADRM1:26S proteasome [cytosol] (Homo sapiens)

Inferred To

adrm1-2 [cytosol] (Dictyostelium discoideum)

rpn1301 [cytosol] (Schizosaccharomyces pombe)

Rpn13 [cytosol] (Drosophila melanogaster)

ADRM1 [cytosol] (Bos taurus)

ADRM1 [cytosol] (Canis familiaris)

ADRM1 [cytosol] (Plasmodium falciparum)

ADRM1 [cytosol] (Sus scrofa)

Ghost homologue of ADRM1 [cytosol] (Saccharomyces cerevisiae)

adrm1b [cytosol] (Danio rerio)

Adrm1 [cytosol] (Mus musculus)

Adrm1 [cytosol] (Rattus norvegicus)

rpn-13 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_008933.2, NP_001268367.1, NP_001268366.1, XP_005260314.1, NP_783163.1

OpenTargets

ENSG00000130706

GeneCards

Q16186

HPA

ENSG00000130706-ADRM1

Ensembl

ENSP00000253003, ENST00000253003, ENSG00000130706, ENSP00000478877, ENST00000491935

PRO

Q16186

Pharos - Targets

Q16186

PDB

4WLQ, 6CO4, 2NBV, 7KXI, 2KR0, 6UYI, 4WLR, 5V1Y, 2MKZ, 6UYJ, 5V1Z, 5IRS, 4UEL, 6OI4, 2L5V, 5YMY, 4UEM, 2KQZ

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.961	21
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.713	5
IntAct:EBI-4399559 UBIQ			0.709	4
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.676	5
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.669	4
UniProt:P55036 PSMD4	2	PSMD4 [nucleoplasm] (R-HSA-174330) PSMD4 [cytosol] (R-HSA-68800)	0.669	5
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.643	4
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.643	4
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.643	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.609	11
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.602	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.592	4
UniProt:Q9Y5K5-3 UCHL5			0.556	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.527	3
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.527	3
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.527	3
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.527	3
UniProt:Q16401 PSMD5	2	PSMD5 [nucleoplasm] (R-HSA-174346) PSMD5 [cytosol] (R-HSA-68802)	0.527	2
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.527	3
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.527	3
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O35593	5	PSMD14 [secretory granule lumen] (R-MMU-6800926) PSMD14 [extracellular region] (R-MMU-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-MMU-6800419) PSMD14 [nucleoplasm] (R-MMU-174329) PSMD14 [cytosol] (R-MMU-68722)	0.499	2
UniProt:P60896 SEM1	2	SEM1 [nucleoplasm] (R-HSA-8866665) SEM1 [cytosol] (R-HSA-8866674)	0.462	3

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