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ADRM1 [cytosol]
Stable Identifier
R-HSA-5665939
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proteasomal ubiquitin receptor ADRM1, ADRM1_HUMAN, Rpn13 homolog
Locations in the PathwayBrowser for interactor UniProt:Q9Y5K5-3 UCHL5
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1 binds 26S proteasome (Homo sapiens)
ADRM1 [cytosol] (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the 19S regulatory particle base precursor (Homo sapiens)
ADRM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16186 ADRM1
Gene Names
ADRM1, GP110
Chain
initiator methionine:1, chain:2-407
Reference Genes
BioGPS Gene:11047 ADRM1
COSMIC (genes):ADRM1 ADRM1
CTD Gene:11047 ADRM1
dbSNP Gene:11047 ADRM1
ENSEMBL:ENSG00000130706 ADRM1
HGNC:15759 ADRM1
KEGG:hsa:11047 ADRM1
Monarch:11047 ADRM1
NCBI Gene:11047 ADRM1
OMIM:610650 ADRM1
UCSC:Q16186 ADRM1
Reference Transcript
RefSeq:NM_001281438.1 ADRM1
RefSeq:NM_001281437.1 ADRM1
RefSeq:NM_175573.2 ADRM1
RefSeq:NM_007002.3 ADRM1
RefSeq:XM_005260257.1 ADRM1
Other Identifiers
11047
11716498_s_at
11716499_x_at
11750079_a_at
16915656
201281_PM_at
201281_at
38808_at
3892610
3892611
3892612
3892613
3892614
3892615
3892616
3892617
3892618
3892620
3892621
3892622
3892628
3892633
3892634
3892635
3892636
3892637
3892638
3892639
3892641
3892642
3892644
3892646
3892647
3892648
8063893
A_14_P126714
A_14_P200578
A_23_P68665
A_24_P305597
D64154_at
GE57289
GO:0000502
GO:0002020
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006368
GO:0008541
GO:0030163
GO:0043161
GO:0043248
GO:0061133
GO:0065003
GO:0070628
GO:0098772
GO:0140678
HMNXSV003021553
ILMN_1760143
ILMN_2389013
PH_hs_0005036
TC20000487.hg
g5901959_3p_at
Participates
as an input of
ADRM1 binds 26S proteasome (Homo sapiens)
Formation of the 19S regulatory particle base precursor (Homo sapiens)
as a component of
ADRM1:26S proteasome [cytosol] (Homo sapiens)
19S RP base precursor [cytosol] (Homo sapiens)
19S RP base [cytosol] (Homo sapiens)
Other forms of this molecule
ADRM1 [nucleoplasm]
Inferred To
rpn1301 [cytosol]
(Schizosaccharomyces pombe)
Rpn13 [cytosol]
(Drosophila melanogaster)
ADRM1 [cytosol]
(Canis familiaris)
ADRM1 [cytosol]
(Gallus gallus)
ADRM1 [cytosol]
(Plasmodium falciparum)
ADRM1 [cytosol]
(Sus scrofa)
bADRM1 [cytosol]
(Bos taurus)
Ghost homologue of ADRM1 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of ADRM1 [cytosol]
(Xenopus tropicalis)
adrm1b [cytosol]
(Danio rerio)
Adrm1 [cytosol]
(Mus musculus)
Adrm1 [cytosol]
(Rattus norvegicus)
adrm1-1; adrm1-2 [cytosol]
(Dictyostelium discoideum)
rpn-13 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_783163.1
,
XP_005260314.1
,
NP_001268367.1
,
NP_001268366.1
,
NP_008933.2
ENSEMBL
ENSP00000253003
,
ENSG00000130706
,
ENSP00000478877
,
ENST00000253003
,
ENST00000491935
OpenTargets
ENSG00000130706
GeneCards
ADRM1
HPA
ENSG00000130706-ADRM1
PRO
Q16186
Pharos - Targets
Q16186
GlyGen
Q16186
PDB
4UEM
,
4WLR
,
4UEL
,
2L5V
,
7KXI
,
2KQZ
,
6OI4
,
5IRS
,
4WLQ
,
2MKZ
,
2NBV
,
6UYJ
,
5YMY
,
5V1Y
,
8FTQ
,
6CO4
,
5V1Z
,
2KR0
,
6UYI
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.965
24
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.788
7
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.764
6
UniProt:Q99460 PSMD1
4
PSMD1 [cytosol]
(R-HSA-68786)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [extracellular region]
(R-HSA-6806194)
0.75
7
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.744
6
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.725
6
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.725
5
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.725
6
UniProt:O00487 PSMD14
5
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.725
5
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.713
5
IntAct:EBI-4399559 UBIQ
0.709
4
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.643
5
UniProt:P48556 PSMD8
2
PSMD8 [cytosol]
(R-HSA-68808)
PSMD8 [nucleoplasm]
(R-HSA-174318)
0.643
4
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.643
4
UniProt:O00231 PSMD11
5
PSMD11 [cytosol]
(R-HSA-68790)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
0.643
5
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.643
5
UniProt:P43686 PSMC4
2
PSMC4 [cytosol]
(R-HSA-68777)
PSMC4 [nucleoplasm]
(R-HSA-174315)
0.643
5
UniProt:O00232 PSMD12
5
PSMD12 [cytosol]
(R-HSA-68792)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
0.643
5
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.643
4
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.643
4
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.643
4
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-386-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783067)
Ub-6-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783122)
0.609
11
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.592
4
UniProt:Q9Y5K5-3 UCHL5
0.556
5
UniProt:P00533 EGFR
20
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
0.553
2
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q5VYK3 ECM29
0.527
3
UniProt:A2A3N6 PIPSL
0.527
2
UniProt:Q5JXX7 TMM31
0.527
2
UniProt:Q53HC0 CCD92
0.527
3
UniProt:O35593
5
Psmd14 [ficolin-1-rich granule lumen]
(R-MMU-6800419)
Psmd14 [extracellular region]
(R-MMU-6806511)
Psmd14 [secretory granule lumen]
(R-MMU-6800926)
Psmd14 [nucleoplasm]
(R-MMU-174329)
Psmd14 [cytosol]
(R-MMU-68722)
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.483
9
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.462
3
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