Reactome: A Curated Pathway Database

RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1

Stable Identifier
R-HSA-5665982
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once activated by binding to RHOA:GTP, DIAPH1 binds profilin:G-actin complexes together with EVL (VASP) homotetramers and promotes elongation of actin filaments (Copeland and Treisman 2002, Grosse et al. 2003, Kursula et al. 2008, Breitsprecher et al. 2008). Binding of nonpolymerized actin (G-actin) to DIAPH1 and EVL releases MKL1 (MAL) transcription co-factor which is inhibited when bound to G-actin (Miralles et al. 2003).

Literature References
Participants
Participant Of
Orthologous Events