Reactome | DIAPH1 binds RHOA:GTP

DIAPH1 binds RHOA:GTP

Stable Identifier

R-HSA-5665989

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Summation

DIAPH1 is activated by binding of the DIAPH1 dimer to GTP-bound (active) RHOA. Binding to RHOA releaves the autoinhibitory interaction of DIAPH1 FH3 and DAD domains (Otomo et al. 2005). Phosphorylation of RHOA at serine residue S188 may be required for RHOA binding to DIAPH1 (Li and Sewer 2010). The interaction between RHOA and DIAPH1 may also be positively regulated by PI3K signaling (Gao et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
20591975	RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking Li, D, Sewer, MB	Endocrinology	2010
20030946	[PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation] Gao, GX, Dong, HJ, Gu, HT, Gao, Y, Pan, YZ, Yang, Y, Chen, XQ	Zhongguo Shi Yan Xue Ye Xue Za Zhi	2009
15866170	Structural basis of Rho GTPase-mediated activation of the formin mDia1 Otomo, T, Otomo, C, Tomchick, DR, Machius, M, Rosen, MK	Mol. Cell	2005