MKL1 translocates from cytosol to the nucleus

Stable Identifier
R-HSA-5665999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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MKL1 translocates from cytosol to the nucleus
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The release of MKL1 (MAL) from nonpolymerized actin (G-actin), after profilin:G-actin complexes bind DIAPH1 and EVL (VASP) downstream of activated RHOA, enables MKL1 to translocate from the cytosol to the nucleus (Miralles et al. 2003).

Literature References
PubMed ID Title Journal Year
12732141 Actin dynamics control SRF activity by regulation of its coactivator MAL

Posern, G, Treisman, R, Miralles, F, Zaromytidou, AI

Cell 2003
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Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
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