Reactome | MKL1 translocates from cytosol to the nucleus

MKL1 translocates from cytosol to the nucleus

Stable Identifier

R-HSA-5665999

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Locations in the PathwayBrowser

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Summation

The release of MKL1 (MAL) from nonpolymerized actin (G-actin), after profilin:G-actin complexes bind DIAPH1 and EVL (VASP) downstream of activated RHOA, enables MKL1 to translocate from the cytosol to the nucleus (Miralles et al. 2003).

Literature References

12732141

Actin dynamics control SRF activity by regulation of its coactivator MAL

Cell

2003

Participants

input

MKL1 [cytosol] (Homo sapiens)

output

MKL1 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

RHO GTPases Activate Formins

Orthologous Events

MKL1 translocates from cytosol to the nucleus (Bos taurus)
MKL1 translocates from cytosol to the nucleus (Canis familiaris)
MKL1 translocates from cytosol to the nucleus (Danio rerio)
MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)
MKL1 translocates from cytosol to the nucleus (Gallus gallus)
MKL1 translocates from cytosol to the nucleus (Mus musculus)
MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)
MKL1 translocates from cytosol to the nucleus (Sus scrofa)
MKL1 translocates from cytosol to the nucleus (Taeniopygia guttata)
MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)