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SRF:MKL1:SCAI [nucleoplasm]
Stable Identifier
R-HSA-5666007
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
SCAI binds SRF:MKL1 (Homo sapiens)
SRF:MKL1:SCAI [nucleoplasm] (Homo sapiens)
SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)
SRF:MKL1:SCAI [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19350017
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin
Kitzing, TM
,
Grosse, R
,
Brandt, DT
,
Ivaska, J
,
Nollau, P
,
Kremmer, E
,
Baarlink, C
Nat. Cell Biol.
2009
Participants
components
SCAI [nucleoplasm]
(Homo sapiens)
SRF:MKL1 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
SCAI binds SRF:MKL1 (Homo sapiens)
This entity regulates
Negatively
SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it
(Homo sapiens)
Inferred To
SRF:MKL1:SCAI [nucleoplasm]
(Bos taurus)
SRF:MKL1:SCAI [nucleoplasm]
(Canis familiaris)
SRF:MKL1:SCAI [nucleoplasm]
(Drosophila melanogaster)
SRF:MKL1:SCAI [nucleoplasm]
(Gallus gallus)
SRF:MKL1:SCAI [nucleoplasm]
(Mus musculus)
SRF:MKL1:SCAI [nucleoplasm]
(Rattus norvegicus)
SRF:MKL1:SCAI [nucleoplasm]
(Sus scrofa)
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