Reactome: A Curated Pathway Database

SCAI binds SRF:MKL1

Stable Identifier
R-HSA-5666008
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SCAI forms a ternary complex with MKL1 and SRF, inhibiting the transcriptional activity of the SRF:MKL1 complex. SCAI negatively regulates cancer cell invasion facilitated by the SRF:MKL1-mediated transcription downstream of RHOA and DIAPH1, and therefore acts as a tumor suppressor (Brandt et al. 2009).

Literature References
Participants
Participant Of
Orthologous Events