SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

Stable Identifier
R-HSA-5666049
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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Summation

SRF:MKL1 binding to the promoter region of the integrin beta-1 gene stimulates ITGB1 expression downstream of RHOA:GTP:DIAPH1-induced actin cytoskeleton changes. Binding of SCAI to SRF:MKL1 inhibits RHOA:GTP:DIAPH1-induced ITGB1 transcription (Brandt et al. 2009).

Literature References
PubMed ID Title Journal Year
19350017 SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

Brandt, DT, Baarlink, C, Kitzing, TM, Kremmer, E, Ivaska, J, Nollau, P, Grosse, R

Nat. Cell Biol. 2009
Participants
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Participant Of
hasEvent
This entity is regulated by
Negative Regulation
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