SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

Stable Identifier
R-HSA-5666049
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
Locations in the PathwayBrowser
Expand all
Summation

SRF:MKL1 binding to the promoter region of the integrin beta-1 gene stimulates ITGB1 expression downstream of RHOA:GTP:DIAPH1-induced actin cytoskeleton changes. Binding of SCAI to SRF:MKL1 inhibits RHOA:GTP:DIAPH1-induced ITGB1 transcription (Brandt et al. 2009).

Literature References
Participants
Input
Output
Participant Of
hasEvent
This entity is regulated by
Negative Regulation
Positive Regulation