SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it

Stable Identifier
R-HSA-5666049
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
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SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it
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SRF:MKL1 binding to the promoter region of the integrin beta-1 gene stimulates ITGB1 expression downstream of RHOA:GTP:DIAPH1-induced actin cytoskeleton changes. Binding of SCAI to SRF:MKL1 inhibits RHOA:GTP:DIAPH1-induced ITGB1 transcription (Brandt et al. 2009).

Literature References
PubMed ID Title Journal Year
19350017 SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

Brandt, DT, Baarlink, C, Kitzing, TM, Kremmer, E, Ivaska, J, Nollau, P, Grosse, R

Nat. Cell Biol. 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SRF:MKL1:SCAI [nucleoplasm] (Homo sapiens)
Positively by
Regulator
SRF:MKL1:ITGB1 Gene [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
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