Reactome | CDC42:GTP recruits DIAPH2-2 to kinetochores

CDC42:GTP recruits DIAPH2-2 to kinetochores

Stable Identifier

R-HSA-5666129

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

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CDC42:GTP recruits DIAPH2-2 to kinetochores

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Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15085137	Cdc42 and mDia3 regulate microtubule attachment to kinetochores Yasuda, S, Oceguera-Yanez, F, Kato, T, Okamoto, M, Yonemura, S, Terada, Y, Ishizaki, T, Narumiya, S	Nature	2004