CDC42:GTP recruits DIAPH2-2 to kinetochores

Stable Identifier
R-HSA-5666129
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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CDC42:GTP recruits DIAPH2-2 to kinetochores
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Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).

Literature References
PubMed ID Title Journal Year
15085137 Cdc42 and mDia3 regulate microtubule attachment to kinetochores

Narumiya, S, Ishizaki, T, Kato, T, Okamoto, M, Yasuda, S, Oceguera-Yanez, F, Yonemura, S, Terada, Y

Nature 2004
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Orthologous Events
CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Danio rerio)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Sus scrofa)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-21)
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