Reactome: A Curated Pathway Database

CDC42:GTP recruits DIAPH2-2 to kinetochores

Stable Identifier
R-HSA-5666129
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events