Reactome: A Curated Pathway Database

AURKB phosphorylates DIAPH2-2 at kinetochores

Stable Identifier
R-HSA-5666160
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Aurora kinase B (AURKB), which is part of the kinetochore, phosphorylates DIAPH2-2 (DIA-12C, mDia3) on serine residue S196 in the FH3 (DID) domain and probably on several other residues in the FH3 and FH2 domains. AURKB-mediated phosphorylation of DIAPH2-2 is necessary for the regulation of microtubule binding to kinetochores by the CDC42:GTP:DIAPH2-2 complex (Cheng et al. 2011).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events