RTKN binds RHOA, RHOC or RHOB

Stable Identifier
R-HSA-5666178
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Rhotekin (RTKN) has the evolutionarily conserved RHO GTPase binding domain at its N-terminus and strongly binds to RHOA and RHOC. RTKN also associates with RHOB with a lower affinity and does not bind RAC1 or CDC42 (Reid et al. 1996). Binding of RTKN may inhibit the GTPase activity of RHO GTPases (Fu et al. 2000).

Literature References
PubMed ID Title Journal Year
10873388 Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286

Fu, Q, Yu, L, Liu, Q, Zhang, J, Zhang, H, Zhao, S

Genomics 2000
8662891 Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

Reid, T, Furuyashiki, T, Ishizaki, T, Watanabe, G, Watanabe, N, Fujisawa, K, Morii, N, Madaule, P, Narumiya, S

J. Biol. Chem. 1996
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