Reactome: A Curated Pathway Database

RTKN binds RHOA, RHOC or RHOB

Stable Identifier
R-HSA-5666178
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Rhotekin (RTKN) has the evolutionarily conserved RHO GTPase binding domain at its N-terminus and strongly binds to RHOA and RHOC. RTKN also associates with RHOB with a lower affinity and does not bind RAC1 or CDC42 (Reid et al. 1996). Binding of RTKN may inhibit the GTPase activity of RHO GTPases (Fu et al. 2000).

Literature References
Participants
Participant Of
Inferred From