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CD27 [plasma membrane]
Stable Identifier
R-HSA-5666994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD27 antigen, CD27_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
CD70 binds CD27 (Homo sapiens)
CD27 [plasma membrane] (Homo sapiens)
CD27:CD70 homotrimer [plasma membrane] (Homo sapiens)
CD27 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26842 CD27
Gene Names
CD27, TNFRSF7
Chain
signal peptide:1-19, chain:20-260
Reference Genes
BioGPS Gene:939 CD27
COSMIC (genes):CD27 CD27
CTD Gene:939 CD27
dbSNP Gene:939 CD27
ENSEMBL:ENSG00000139193 CD27
ENSEMBL_homo_sapiens_GENE:ENSG00000139193.4 CD27
HGNC:11922 CD27
KEGG Gene (Homo sapiens):939 CD27
Monarch:939 CD27
NCBI Gene:939 CD27
OMIM:186711 CD27
UCSC:P26842 CD27
Reference Transcript
RefSeq:NM_001242.4 CD27
Other Identifiers
11725481_a_at
16747261
206150_PM_at
206150_at
3402507
3402508
3402509
3402511
3402513
3402514
3402516
3402517
3402518
3402519
3402521
38578_at
7953333
939
A_14_P139106
A_14_P200329
A_23_P48088
GE61298
GO:0002376
GO:0004888
GO:0005515
GO:0005576
GO:0005886
GO:0006915
GO:0007155
GO:0007166
GO:0009897
GO:0009986
GO:0012501
GO:0016020
GO:0016064
GO:0023052
GO:0030154
GO:0043027
GO:0043066
GO:0045471
GO:0045579
GO:0045582
GO:0046330
GO:0048856
GO:0060089
GO:0070233
GO:0097191
GO:0098772
GO:1901224
HMNXSV003031034
ILMN_1688959
M63928_at
PH_hs_0017208
TC12000080.hg
g4507586_3p_at
Participates
as a component of
CD27:CD70 homotrimer [plasma membrane] (Homo sapiens)
as an input of
CD70 binds CD27 (Homo sapiens)
Inferred To
Cd27 [plasma membrane]
(Mus musculus)
CD27 [plasma membrane]
(Bos taurus)
CD27 [plasma membrane]
(Canis familiaris)
CD27 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001233.1
Guide to Pharmacology - Targets
1876
OpenTargets
ENSG00000139193
HPA
ENSG00000139193-CD27
GeneCards
P26842
Ensembl
ENSG00000139193
,
ENSP00000266557
,
ENST00000266557
PRO
P26842
Pharos - Targets
P26842
Orphanet
22186
PDB
5TLJ
,
5TL5
,
7KX0
,
5TLK
,
8DS5
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15304 SIVA
0.635
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:Q99828 CIB1
0.556
7
UniProt:P0DTD1-PRO_0000449624 REP
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.547
3
UniProt:Q8TBA6 GOLGA5
2
GOLGA5 [transport vesicle]
(R-HSA-8847517)
GOLGA5 [Golgi membrane]
(R-HSA-8847514)
0.527
3
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
2
UniProt:O60503 ADCY9
1
ADCY9 [plasma membrane]
(R-HSA-379055)
0.527
2
UniProt:O60779 SLC19A2
1
SLC19A2 [plasma membrane]
(R-HSA-199636)
0.527
2
UniProt:P32970 CD70
1
CD70 [plasma membrane]
(R-HSA-5667139)
0.527
2
UniProt:Q9H1U9 S2551
0.527
3
UniProt:A6NFQ2 TCAF2
0.527
3
UniProt:Q5HYA8 TMEM67
1
TMEM67 [ciliary membrane]
(R-HSA-5626667)
0.527
3
UniProt:Q02383 SEMG2
0.527
2
UniProt:O15126 SCAMP1
2
SCAMP1 [plasma membrane]
(R-HSA-6806161)
SCAMP1 [specific granule membrane]
(R-HSA-6806140)
0.527
2
UniProt:P04279 SEMG1
2
SEMG1 [extracellular region]
(R-HSA-977100)
hC239-SEMG1 [extracellular region]
(R-HSA-6810688)
0.527
2
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