RHOA:GTP binds RHPN1 or RHPN2

Stable Identifier
R-HSA-5667008
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated RHOA (RHOA:GTP) binds rhophilin-1 (RHPN1) or rophilin-2 (RHPN2). RHPN1 and RHPN2 share 75% sequence identity, with the RHO-binding domain at the N-terminus, followed by the BRO1 domain in their central region (characteristic of proteins involved in protein kinase C signaling), and the PDZ domain in the C-terminal region. PDZ domains of RHPN1 and RHPN2 exhibit little homology (Watanabe et al. 1996, Peck et al. 2002). RHPN2 may be involved in the regulation of the actin cytoskeleton organization downstream of RHOA (Peck et al. 2002).

Literature References
PubMed ID Title Journal Year
12221077 The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization

Peck, JW, Oberst, M, Bouker, KB, Bowden, E, Burbelo, PD

J. Biol. Chem. 2002
8571126 Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

Watanabe, G, Saito, Y, Madaule, P, Ishizaki, T, Fujisawa, K, Morii, N, Mukai, H, Ono, Y, Kakizuka, A, Narumiya, S

Science 1996
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