Reactome | RHOA:GTP binds RHPN1 or RHPN2

RHOA:GTP binds RHPN1 or RHPN2

Stable Identifier

R-HSA-5667008

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated RHOA (RHOA:GTP) binds rhophilin-1 (RHPN1) or rophilin-2 (RHPN2). RHPN1 and RHPN2 share 75% sequence identity, with the RHO-binding domain at the N-terminus, followed by the BRO1 domain in their central region (characteristic of proteins involved in protein kinase C signaling), and the PDZ domain in the C-terminal region. PDZ domains of RHPN1 and RHPN2 exhibit little homology (Watanabe et al. 1996, Peck et al. 2002). RHPN2 may be involved in the regulation of the actin cytoskeleton organization downstream of RHOA (Peck et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8571126	Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho Madaule, P, Kakizuka, A, Mukai, H, Fujisawa, K, Narumiya, S, Watanabe, G, Ishizaki, T, Saito, Y, Morii, N, Ono, Y	Science	1996
12221077	The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization Bouker, KB, Burbelo, PD, Peck, JW, Oberst, M, Bowden, E	J. Biol. Chem.	2002