RHPN2 binds RHOB:GTP

Stable Identifier
R-HSA-5667037
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RHPN2 (rhophilin-2) binds to activated RHOB (RHOB:GTP) and relocalizes to endosomal membrane. The expression of the mouse Rhpn2 in thyrocytes increases upon TSH stimulation (Mircescu et al. 2002). This implied an important function of Rhpn2 in the thyroid, but Rhpn2 deficient mice exhibit normal thyroid structure and function, as well as an overall normal development (Behrends et al. 2005).

Literature References
PubMed ID Title Journal Year
12473120 Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP

Mircescu, H, Steuve, S, Savonet, V, Degraef, C, Mellor, H, Dumont, JE, Maenhaut, C, Pirson, I

Eur. J. Biochem. 2002
15767687 Normal thyroid structure and function in rhophilin 2-deficient mice

Behrends, J, Clément, S, Pajak, B, Pohl, V, Maenhaut, C, Dumont, JE, Schurmans, S

Mol. Cell. Biol. 2005
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