Reactome: A Curated Pathway Database

PARK2 K63-Ubiquitinates SNCAIP

Stable Identifier
R-HSA-5667111
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SNCAIP is ubiquitinated by several different E3 ubiquitin-ligases, including Parkin (PARK2). PARK2 overexpression with SNCAIP in cell culture leads to the formation of protein aggregates (Chung et al. 2001). PARK2 preferentially mediates the addition of lysine-63 (K63)-linked polyubiquitination of SNCAIP (Lim et al. 2005). This leads to SNCAIP degradation only at an unusually high PARK2 to SNCAIP ratio (Lim et al. 2005). K63-linked ubiquitination may be a signal that leads to the degradation of inclusions by autophagy when the ubiquitin-proteasome system is dysfunctional (Lim et al. 2005, Tan et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of PARK2:SNCAIP [cytosol] PARK2:SNCAIP [cytosol] ubiquitin-protein transferase activity (0004842)