Reactome | RUNX1 [plasma membrane]

RUNX1 [plasma membrane]

Stable Identifier

R-HSA-5667138

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Runt-related transcription factor 1, RUNX1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P17542 TAL1

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External Reference Information

External Reference

UniProt:Q01196 RUNX1

Gene Names

RUNX1, AML1, CBFA2

Chain

chain:1-453

Reference Genes

BioGPS Gene:861 RUNX1

COSMIC (genes):RUNX1 RUNX1

CTD Gene:861 RUNX1

dbSNP Gene:861 RUNX1

ENSEMBL:ENSG00000159216 RUNX1

HGNC:10471 RUNX1

KEGG:hsa:861 RUNX1

Monarch:861 RUNX1

NCBI Gene:861 RUNX1

OMIM:151385 RUNX1

UCSC:Q01196 RUNX1

Reference Transcript

This entity regulates

Negatively

SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)

Other forms of this molecule

RUNX1 [nucleoplasm]

MeR206,MeR210-RUNX1 [nucleoplasm]

p-7Y-RUNX1 [nucleoplasm]

p-S249,T273,S276-RUNX1 [nucleoplasm]

Inferred To

Runx1 [plasma membrane] (Mus musculus)

Runx1 [plasma membrane] (Rattus norvegicus)

RUNX1 [plasma membrane] (Bos taurus)

RUNX1 [plasma membrane] (Gallus gallus)

RUNX1 [plasma membrane] (Sus scrofa)

rnt-1 [plasma membrane] (Caenorhabditis elegans)

run [plasma membrane] (Drosophila melanogaster)

runx1 [plasma membrane] (Danio rerio)

runx1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001116079.1, XP_011528068.1, XP_054180870.1, XP_047296963.1, NP_001745.2, XP_005261125.1, XP_054180869.1, NP_001001890.1, XP_054180871.1

OpenTargets

ENSG00000159216

ENSEMBL

ENST00000344691, ENST00000358356, ENST00000300305, ENSP00000300305, ENSP00000340690, ENSG00000159216, ENSP00000351123, ENST00000675419, ENSP00000501943

HPA

ENSG00000159216-RUNX1

GeneCards

RUNX1

PRO

Q01196

Pharos - Targets

Q01196

GlyGen

Q01196

Orphanet

RUNX1

PDB

1LJM, 1CO1, 1CMO, 1E50, 1H9D

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.872	7
UniProt:Q9H2X6 HIPK2	3	HIPK2 [nucleoplasm] (R-HSA-3215222) p-HIPK2 [nucleoplasm] (R-HSA-6799375) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.639	4
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.628	5
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.623	3
UniProt:Q15723 ELF2	1	ELF2 [nucleoplasm] (R-HSA-8938898)	0.544	2
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.527	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.454	2

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