26Sproteasome degrades K48polyUb-NIK

Stable Identifier
R-HSA-5668520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Polyubiquitinated NIK is targeted for proteasomal degradation and as a consequence the NIK levels are invisible and thus prevent non-canonical NF-kB activation.

Literature References
PubMed ID Title Journal Year
10797013 Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

Yang, Y, Fang, S, Jensen, JP, Weissman, AM, Ashwell, JD

Science 2000
18997794 Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Zarnegar, BJ, Wang, Y, Mahoney, DJ, Dempsey, PW, Cheung, HH, He, J, Shiba, T, Yang, X, Yeh, WC, Mak, TW, Korneluk, RG, Cheng, G

Nat. Immunol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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