Reactome | K48polyUb-NIK [cytosol]

K48polyUb-NIK [cytosol]

Stable Identifier

R-HSA-5668525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP3K14, Mitogen-activated protein kinase kinase kinase 14, NF-kB inducing kinase

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External Reference Information

External Reference

UniProt:Q99558 MAP3K14

Gene Names

MAP3K14, NIK

Chain

chain:1-947

Reference Genes

BioGPS Gene:9020 MAP3K14

COSMIC (genes):MAP3K14 MAP3K14

CTD Gene:9020 MAP3K14

dbSNP Gene:9020 MAP3K14

ENSEMBL:ENSG00000006062 MAP3K14

ENSEMBL:ENSG00000006062.18 MAP3K14

HGNC:6853 MAP3K14

KEGG Gene (Homo sapiens):9020 MAP3K14

Monarch:9020 MAP3K14

NCBI Gene:9020 MAP3K14

OMIM:604655 MAP3K14

UCSC:Q99558 MAP3K14

Reference Transcript

Other Identifiers

11724902_a_at

11724903_a_at

16845876

205192_PM_at

205192_at

3759702

3759703

3759705

3759706

3759707

3759708

3759709

3759710

3759712

3759713

3759717

3759719

3759720

3759721

3759722

3759730

3759732

3759733

3759734

3759735

3759736

3759737

3759740

3759741

3759749

3759752

8016194

9020

974_at

A_23_P207319

GE60277

GO:0000165

GO:0000166

GO:0001650

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004704

GO:0004709

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006468

GO:0006955

GO:0007249

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0036211

GO:0038061

GO:0043123

GO:0043226

GO:0043231

GO:0051607

GO:0071260

GO:0098542

GO:0098772

GO:0106310

GO:0140096

HMNXSV003030142

ILMN_1724070

PH_hs_0025776

TC17001598.hg

Y10256_at

g4505396_3p_at

p33461

Participates

as an input of

26Sproteasome degrades K48polyUb-NIK (Homo sapiens)

as an output of

cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)

Other forms of this molecule

p-T559-MAP3K14 [cytosol]

Active NIK [cytosol]

MAP3K14 [cytosol]

p-MAP3K14 [cytosol]

Inferred To

K48polyUb-NIK [cytosol] (Bos taurus)

K48polyUb-NIK [cytosol] (Canis familiaris)

K48polyUb-NIK [cytosol] (Danio rerio)

K48polyUb-NIK [cytosol] (Gallus gallus)

K48polyUb-NIK [cytosol] (Mus musculus)

K48polyUb-NIK [cytosol] (Saccharomyces cerevisiae)

K48polyUb-NIK [cytosol] (Sus scrofa)

K48polyUb-NIK [cytosol] (Xenopus tropicalis)

Map3k14 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003945.2, XP_011523743.1

Guide to Pharmacology - Targets

2074

OpenTargets

ENSG00000006062

ZINC - Substances

M3K14_HUMAN

ZINC target

Q99558

ZINC - Biogenic

M3K14_HUMAN

PRO

Q99558

PDB

4IDV, 4G3D, 6Z1Q, 4DN5, 6WPP, 6Z1T, 4IDT

GeneCards

Q99558

HPA

ENSG00000006062-MAP3K14

Ensembl

ENSP00000478552, ENST00000617331, ENSG00000006062, ENST00000344686, ENSP00000482657, ENST00000376926, ENSP00000480974

Pharos - Targets

Q99558

ZINC - Predictions - Purchasable

M3K14_HUMAN

Orphanet

23729

HMDB Protein

HMDBP01177

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.941	13
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.887	9
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.87	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.813	6
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.758	6
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.749	9
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.744	5
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.669	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.669	4
UniProt:Q9Y5L4 TIMM13	2	TIMM13 [mitochondrial intermembrane space] (R-HSA-1307781) 4xHC-TIMM13 [mitochondrial intermembrane space] (R-HSA-1252199)	0.643	4
UniProt:Q00653 NFKB2	6	monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) NFKB2(1-900) [cytosol] (R-HSA-2677931) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629) NFKB2(1-454) [cytosol] (R-HSA-168144) NFKB2(1-454) [nucleoplasm] (R-HSA-177674)	0.643	4
UniProt:P05186 ALPL	2	cleaved GPI-ALPL [extracellular region] (R-HSA-8943383) GPI-ALPL [plasma membrane] (R-HSA-8940714)	0.611	4
UniProt:P61353 RPL27	1	RPL27 [cytosol] (R-HSA-72440)	0.564	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.564	3
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.564	3
UniProt:P62269 RPS18	2	RPS18 [nucleoplasm] (R-HSA-6798701) RPS18 [cytosol] (R-HSA-72341)	0.564	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.564	3
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.564	3
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.564	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.564	3
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [secretory granule lumen] (R-HSA-6801472) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512)	0.564	3
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.564	3
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.564	3
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.564	3
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.564	3
UniProt:Q02878 RPL6	1	RPL6 [cytosol] (R-HSA-72484)	0.564	3
UniProt:Q96L21 RPL10L	1	RPL10L [cytosol] (R-HSA-8868799)	0.564	3
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.564	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.564	3
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.564	3
UniProt:P39023 RPL3	1	RPL3 [cytosol] (R-HSA-72448)	0.564	3
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.564	2
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.564	3
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.564	3
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.564	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.564	3
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.564	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.564	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q60680-2 CHUK			0.544	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.536	2
UniProt:Q9Y5A9 YTHD2			0.527	2
UniProt:Q7L2E3 DHX30			0.527	2
UniProt:Q9Y5J9 TIMM8B	2	TIMM8B [mitochondrial intermembrane space] (R-HSA-1307790) 4xHC-TIMM8B [mitochondrial intermembrane space] (R-HSA-1252067)	0.527	2
UniProt:O60220 TIMM8A	2	TIMM8A [mitochondrial intermembrane space] (R-HSA-1307780) 4xHC-TIMM8A [mitochondrial intermembrane space] (R-HSA-1252065)	0.527	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714)	0.499	2

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