NIK autophosphorylates on T559

Stable Identifier
R-HSA-5668545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Signal-induced NIK accumulation and activation is likely an essential step for triggering the downstream signalling events in non-canonical NF-kB pathway. Like other MAP3Ks NIK may also be triggered by its phosphorylation. It has been suggested that threonine (T559) phosphorylation of NIK is required for its activity. T559 phosphorylation of NIK is likely mediated by autophosphorylation, which could be triggered through NIK accumulation (Lin et al. 1998).

Literature References
PubMed ID Title Journal Year
9742107 Molecular determinants of NF-kappaB-inducing kinase action

Lin, X, Mu, Y, Cunningham, ET, Marcu, KB, Geleziunas, R, Greene, WC

Mol. Cell. Biol. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MAP3K14 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created