Reactome | RAC1:GTP binds NOX1 complex

RAC1:GTP binds NOX1 complex

Stable Identifier

R-HSA-5668714

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Activated RAC1 (RAC1:GTP) binds NADPH oxidase NOX1 complex composed of NOX1, NOXA1, NOXO1 and CYBA (p22phox). RAC1 directly interacts with a conserved region in NOX1 and with tetratricopeptide repeats in NOXA1 (Takeya et al. 2003, Park et al. 2006, Cheng et al. 2006, Miyano et al. 2006, Kao et al. 2008)

Literature References

PubMed ID	Title	Journal	Year
16636067	Nox1-dependent reactive oxygen generation is regulated by Rac1 Lambeth, JD, Diebold, BA, Hughes, Y, Cheng, G	J. Biol. Chem.	2006
16329988	Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1 Park, HS, Bae, YS, Park, D	Biochem. Biophys. Res. Commun.	2006
16762923	Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 Takeya, R, Miyano, K, Sumimoto, H, Ueno, N	J. Biol. Chem.	2006
18347018	Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism Bohl, B, Taylor, RM, Gianni, D, Bokoch, GM, Kao, YY	J. Biol. Chem.	2008
12716910	Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases Takeya, R, Taura, M, Sumimoto, H, Kami, K, Ueno, N, Izaki, T, Nunoi, H, Kohjima, M	J. Biol. Chem.	2003