Reactome | TNFRSF8 [plasma membrane]

TNFRSF8 [plasma membrane]

Stable Identifier

R-HSA-5668758

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD30, Tumor necrosis factor receptor superfamily member 8, TNR8_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q99741 CDC6

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External Reference Information

External Reference

UniProt:P28908 TNFRSF8

Gene Names

TNFRSF8, CD30, D1S166E

Chain

signal peptide:1-18, chain:19-595

Reference Genes

BioGPS Gene:943 TNFRSF8

COSMIC (genes):TNFRSF8 TNFRSF8

CTD Gene:943 TNFRSF8

dbSNP Gene:943 TNFRSF8

ENSEMBL:ENSG00000120949 TNFRSF8

HGNC:11923 TNFRSF8

Monarch:943 TNFRSF8

NCBI Gene:943 TNFRSF8

OMIM:153243 TNFRSF8

UCSC:P28908 TNFRSF8

Reference Transcript

Other Identifiers

11750717_a_at

11755683_a_at

16659217

206729_PM_at

206729_at

2320684

2320685

2320686

2320694

2320696

2320697

2320698

2320701

2320702

2320703

2320706

2320707

2320708

2320709

2320710

2320715

2320716

2320717

2320718

2320719

2320720

34929_at

7897860

943

A_23_P500614

GE79392

GO:0002020

GO:0004888

GO:0005515

GO:0005654

GO:0005737

GO:0005886

GO:0007165

GO:0008285

GO:0032759

GO:0032760

GO:0043065

GO:0043226

GO:0060089

GO:0070062

GO:0071260

HMNXSV003044445

ILMN_1659257

ILMN_1770711

M83554_at

PH_hs_0000178

TC01000154.hg

g4507588_3p_at

Participates

as a component of

TNFSF8:TNFRSF8 [plasma membrane] (Homo sapiens)

as an input of

TNFSF8 binds TNFRSF8 (Homo sapiens)

Inferred To

MIIP [plasma membrane] (Canis familiaris)

TNFRSF8 [plasma membrane] (Bos taurus)

TNFRSF8 [plasma membrane] (Gallus gallus)

Tnfrsf8 [plasma membrane] (Mus musculus)

Tnfrsf8 [plasma membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

1877

ENSEMBL

ENSP00000263932, ENST00000417814, ENST00000413146, ENST00000263932, ENSP00000390650, ENSP00000398337

OpenTargets

ENSG00000120949

HPA

ENSG00000120949-TNFRSF8

PRO

P28908

Pharos - Targets

P28908

GlyGen

P28908

PDB

1D01

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.59	2
UniProt:Q2PZI1 D19L1			0.527	2
UniProt:P61599 NAA20			0.527	2
UniProt:Q99741 CDC6	4	CDC6 [cytosol] (R-HSA-113566) p-CDC6 [cytosol] (R-HSA-68583) p-CDC6 [nucleoplasm] (R-HSA-5661317) CDC6 [nucleoplasm] (R-HSA-68542)	0.527	2
UniProt:Q9Y5K8 ATP6V1D	3	ATP6V1D [plasma membrane] (R-HSA-6800455) ATP6V1D [specific granule membrane] (R-HSA-6799710) ATP6V1D [cytosol] (R-HSA-912597)	0.527	2
UniProt:Q86XZ4 SPAS2			0.527	2
UniProt:O43293 DAPK3	1	DAPK3 [cytosol] (R-HSA-418265)	0.527	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.527	2
UniProt:Q9H4A5 GLP3L			0.527	2
UniProt:Q9Y496 KIF3A	3	KIF3A [cilium] (R-HSA-5610394) KIF3A [cytosol] (R-HSA-984767) KIF3A [ciliary tip] (R-HSA-5625377)	0.527	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.527	2
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.527	2

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