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LA,TNFSF14 binds LTBR
Stable Identifier
R-HSA-5668789
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
LTA/B,TNFSF14 binds TNFR3
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
LA,TNFSF14 binds LTBR (Homo sapiens)
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Lymphotoxin-beta receptor (LTBR or TNFR3) is a tumor necrosis factor receptor superfamily (TNFRSF) member that is expressed in lymphoid stromal and epithelial cells and binds two members of the TNFSF, the lymphotoxin alpha/beta (LTA/B) heterotrimers, as well as homotrimeric TNFSF14 (LIGHT) (Rooney et al. 2000, Aggarwal 2003). Both ligands are cytokines produced by activated lymphocytes that plays an important role in the inflammatory and immunologic response. LTA is a product of stimulated T cells and can help elicit cytotoxic effects on cancer cells (Stopfer et al. 2004, Crowe et al. 1994, Mauri et al. 1998, Ware et al. 1992). LTBR (TNFR3) signalling mediates responses controlling cellular differentiation, development and maintenance of peripheral lymphoid organs, dendritic cell homeostasis, hepatic regeneration, interferon responses to pathogens, and death of mucosal derived carcinomas (Norris & Ware 2007, Schneider et al. 2004).
Participants
Input
LTBR [plasma membrane]
(Homo sapiens)
lymphotoxin,TNFSF14 trimer [plasma membrane]
(Homo sapiens)
Output
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane]
(Homo sapiens)
Entity On Other Cell
lymphotoxin,TNFSF14 trimer [plasma membrane]
(Homo sapiens)
Participates
as an event of
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
Inferred From
Ltbr binds lymphotoxin and Tnfsf14 (Mus musculus)
Authored
Garapati, P V (2015-01-26)
Reviewed
Rajput, A (2015-05-12)
Virgen-Slane, R (2015-05-12)
Ware, CF (2015-05-12)
Created
Garapati, P V (2015-01-28)
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