PAK1 or PAK2 phosphorylates MYLK

Stable Identifier
R-HSA-5668984
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PAK1 and PAK2 phosphorylate and inactivate MYLK (MLCK), a myosin light chain kinase. It is assumed that PAK1 phosphorylates the same sites as PAK2. MYLK serine residues phosphorylated by PAK2 were determined using rabbit recombinant MYLK and human PAK2. Rabbit MYLK serines S439 and S991 are conserved in human MYLK and match S1208 and S1759 (Sanders et al. 1999, Goeckeler et al. 2000). Please note that the recombinant rabbit MYLK sequence is shorter than the canonical human MYLK sequence and corresponds to human MYLK transcription isoforms that lack the first 922 amino acids present in the canonical MYLK isoform.

Literature References
PubMed ID Title Journal Year
10748018 Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2

Goeckeler, ZM, Masaracchia, RA, Zeng, Q, Chew, TL, Gallagher, P, Wysolmerski, RB

J Biol Chem 2000
10092231 Inhibition of myosin light chain kinase by p21-activated kinase

Sanders, LC, Matsumura, F, Bokoch, GM, de Lanerolle, P

Science 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,T-PAK1,2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created