EDA-3 binds EDA2R

Stable Identifier
R-HSA-5669013
Type
Reaction [binding]
Species
Homo sapiens
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Ectodysplasin-A (EDA) is a trimeric type II membrane protein whose sequence includes an interrupted collagenous domain of 19 Gly-X-Y repeats and a motif conserved in the tumor necrosis factor (TNF)-related ligand family. EDA regulates ectodermal appendage formation by colocalising with cytoskeletal structures on cell surfaces (Ezer et al. 1999). Activation of the NF-kappaB pathway by the tumor necrosis factor receptor superfamily member EDAR (EDAR) and its downstream adaptator EDAR-associated death domain (EDARADD) is essential for the development of hair follicles, teeth, exocrine glands and other ectodermal structures. EDA isoform 3 specifically binds tumor necrosis factor receptor superfamily member 27 (EDA2R aka XEDAR) whilst EDA isoform 1 specifcally binds EDAR (Hymowitz et al. 2003).

Literature References
PubMed ID Title Journal Year
14656435 The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity

Hymowitz, SG, Compaan, DM, Yan, M, Wallweber, HJ, Dixit, VM, Starovasnik, MA, de Vos, AM

Structure 2003
10484778 Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells

Ezer, S, BayƩs, M, Elomaa, O, Schlessinger, D, Kere, J

Hum. Mol. Genet. 1999
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